2xaw: Difference between revisions

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==Ribonucleotide reductase Y730NO2Y and Y731F modified R1 subunit of E. coli==
==Ribonucleotide reductase Y730NO2Y and Y731F modified R1 subunit of E. coli==
<StructureSection load='2xaw' size='340' side='right' caption='[[2xaw]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='2xaw' size='340' side='right'caption='[[2xaw]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xaw]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2x5b 2x5b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XAW FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xaw]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2x5b 2x5b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XAW FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NIY:META-NITRO-TYROSINE'>NIY</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rsr|1rsr]], [[1mxr|1mxr]], [[3r1r|3r1r]], [[1pim|1pim]], [[1jqc|1jqc]], [[2r1r|2r1r]], [[4r1r|4r1r]], [[2xav|2xav]], [[2xap|2xap]], [[1piy|1piy]], [[2xak|2xak]], [[1biq|1biq]], [[1rlr|1rlr]], [[1r65|1r65]], [[2alx|2alx]], [[1r1r|1r1r]], [[1av8|1av8]], [[7r1r|7r1r]], [[1xik|1xik]], [[2av8|2av8]], [[1qfn|1qfn]], [[1rnr|1rnr]], [[1rib|1rib]], [[1mrr|1mrr]], [[1jpr|1jpr]], [[5r1r|5r1r]], [[1pj1|1pj1]], [[1pfr|1pfr]], [[6r1r|6r1r]], [[1pj0|1pj0]], [[1rsv|1rsv]], [[1piu|1piu]], [[1yfd|1yfd]], [[1piz|1piz]], [[2x0x|2x0x]], [[1pm2|1pm2]], [[2xaz|2xaz]], [[2xax|2xax]], [[2xay|2xay]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NIY:META-NITRO-TYROSINE'>NIY</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xaw OCA], [https://pdbe.org/2xaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xaw RCSB], [https://www.ebi.ac.uk/pdbsum/2xaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xaw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xaw OCA], [http://pdbe.org/2xaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xaw RCSB], [http://www.ebi.ac.uk/pdbsum/2xaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xaw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines. [[http://www.uniprot.org/uniprot/RIR2_ECOLI RIR2_ECOLI]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.  
[https://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Ribonucleotide reductase|Ribonucleotide reductase]]
*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli]]
[[Category: Ribonucleoside-diphosphate reductase]]
[[Category: Escherichia coli K-12]]
[[Category: Stubbe, J]]
[[Category: Large Structures]]
[[Category: Uhlin, U]]
[[Category: Stubbe J]]
[[Category: Yokoyama, K]]
[[Category: Uhlin U]]
[[Category: Allosteric enzyme]]
[[Category: Yokoyama K]]
[[Category: Alternative initiation]]
[[Category: Dna replication]]
[[Category: Nucleotide-binding]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/2xaw"