2x9n: Difference between revisions

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==High resolution structure of TbPTR1 in complex with cyromazine==
==High resolution structure of TbPTR1 in complex with cyromazine==
<StructureSection load='2x9n' size='340' side='right' caption='[[2x9n]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
<StructureSection load='2x9n' size='340' side='right'caption='[[2x9n]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2x9n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X9N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X9N FirstGlance]. <br>
<table><tr><td colspan='2'>[[2x9n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X9N FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AX3:N~2~-CYCLOPROPYL-1,3,5-TRIAZINE-2,4,6-TRIAMINE'>AX3</scene>, <scene name='pdbligand=D1D:(4S,5S)-1,2-DITHIANE-4,5-DIOL'>D1D</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bmc|3bmc]], [[3bmh|3bmh]], [[3bmf|3bmf]], [[2wd8|2wd8]], [[3bmm|3bmm]], [[3gn1|3gn1]], [[2vz0|2vz0]], [[3gn2|3gn2]], [[3bmg|3bmg]], [[2c7v|2c7v]], [[3bmr|3bmr]], [[3bmn|3bmn]], [[3bmq|3bmq]], [[3bmi|3bmi]], [[3bmj|3bmj]], [[3bml|3bml]], [[3bme|3bme]], [[3bmk|3bmk]], [[3bmo|3bmo]], [[3bmd|3bmd]], [[2wd7|2wd7]], [[2x9v|2x9v]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AX3:N~2~-CYCLOPROPYL-1,3,5-TRIAZINE-2,4,6-TRIAMINE'>AX3</scene>, <scene name='pdbligand=D1D:(4S,5S)-1,2-DITHIANE-4,5-DIOL'>D1D</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pteridine_reductase Pteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.33 1.5.1.33] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x9n OCA], [https://pdbe.org/2x9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x9n RCSB], [https://www.ebi.ac.uk/pdbsum/2x9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x9n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x9n OCA], [http://pdbe.org/2x9n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x9n RCSB], [http://www.ebi.ac.uk/pdbsum/2x9n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x9n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O76290_TRYBB O76290_TRYBB]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pteridine reductase]]
[[Category: Large Structures]]
[[Category: Trybb]]
[[Category: Trypanosoma brucei brucei]]
[[Category: Barrack, K L]]
[[Category: Barrack KL]]
[[Category: Dawson, A]]
[[Category: Dawson A]]
[[Category: Hunter, W N]]
[[Category: Hunter WN]]
[[Category: Tulloch, L B]]
[[Category: Tulloch LB]]
[[Category: Oxidoreductase]]
[[Category: Short chain dehydrogenase]]

Latest revision as of 10:22, 9 May 2024

High resolution structure of TbPTR1 in complex with cyromazine

2x9n, resolution 1.15Å

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