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| <StructureSection load='' size='350' side='right' caption='Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry [[1cqq]])' scene='55/554890/Cv/1'> | | <StructureSection load='' size='350' side='right' caption='Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry [[1cqq]])' scene='55/554890/Cv/1'> |
| __TOC__ | | __TOC__ |
| == Function == | | == Function == |
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| '''3C protease''' (3CP) is a virus cysteine protease which has essential role in viral replication. 3CP cleaves the precursor viral polyprotein to produce functional proteins and enzymes.<ref>PMID:17305557</ref> For more details on Foot and Mouth Disease virus 3C protease see [[FMDV 3C]]. | | '''Virus protease''' or '''3C protease''' or '''virus proteinase''' are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.<ref>PMID:17305557</ref> F |
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| == Disease == | | == Disease == |
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| 3CP is an attractive target for therapeutic agents for treatment of diseases caused by the common cold virus. Coxsakievirus causes the human diseases myocarditis and pericarditis.
| | Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus. Coxsakievirus causes the human diseases myocarditis and pericarditis. |
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| == Structural highlights == | | == Structural highlights == |
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| 3CP - a Cys protease fold is similar to that of trypsin-like serine proteases. The <scene name='55/554890/Cv/6'>active site triad contains Cys147, His40 and Glu71</scene> (PDB entry [[1cqq]]).<ref>PMID:10500114</ref> <scene name='55/554890/Cv/5'>Whole binding site</scene>.
| | Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The <scene name='55/554890/Cv/6'>active site triad contains Cys147, His40 and Glu71</scene> (PDB entry [[1cqq]]).<ref>PMID:10500114</ref> <scene name='55/554890/Cv/5'>Whole binding site</scene>. |
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| See also<br /> | | See also<br /> |
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| *[[Molecular Playground/Dengue Virus Protease]]<br /> | | *[[Molecular Playground/Dengue Virus Protease]]<br /> |
| *[[Viability of a drug-resistant HIV-1 protease mutant]]<br /> | | *[[Viability of a drug-resistant HIV-1 protease mutant]]<br /> |
| *[[Molecular Playground/Dengue Virus Protease]] | | *[[FMDV 3C]] for Foot-and-Mouth virus protease<br /> |
| | *[[SARS Coronavirus Main Proteinase]]<br /> |
| | *[[SARS-CoV-2 Coronavirus Main Protease]]<br /> |
| | *[[Taylor SARS-CoV2 Protease]]<br /> |
| | == 3D Structures of Virus protease == |
| | [[Virus protease 3D structures]] |
| </StructureSection> | | </StructureSection> |
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| == 3D Structures of Virus proteases ==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *'''HIV-1 protease''' . See [[Immunodeficiency virus protease]]
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| *'''HIV-2 protease''' See [[Immunodeficiency virus protease]]
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| *'''Feline Immunodeficiency virus protease''' See [[Immunodeficiency virus protease]]
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| *'''Simian Immunodeficiency virus protease''' See [[Immunodeficiency virus protease]]
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| *'''Xenotropic murine leukemia virus protease'''
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| **[[3nr6]] – XMRV-PR P14<br />
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| **[[3p1g]] – XMRV-PR RNase H domain (mutant)<br />
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| **[[3slz]] – XMRV-PR residues 533-657 + inhibitor<br />
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| **[[3sm1]] – XMRV-PR residues 533-657 + pepstatin<br />
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| **[[3sm2]] – XMRV-PR residues 533-657 + amprenavir<br />
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| *'''Human T-cell leukemia virus protease'''
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| **[[2b7f]] – HTLV-PV + peptide<br />
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| **[[3lin]], [[3liq]], [[3lit]], [[3liv]], [[3lix]], [[3liy]], [[4ydg]], [[4ydf]] – HTLV-PV (mutant) + inhibitor<br />
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| *'''Rous sarcoma virus protease'''
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| **[[2rsp]] – RSVP - Rous sarcoma virus<br/>
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| **[[1bai]] – RSVP + polypeptide inhibitor
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| *'''Human Cytomegalovirus protease'''
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| **[[1wpo]] – CMVP - human herpes virus 5<br />
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| **[[1cmv]], [[1lay]], [[1jq6]], [[1id4]], [[1iec]], [[1ied]], [[1ief]], [[1ieg]] – CMVP (mutant) <br />
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| **[[2wpo]], [[1jq7]] - CMVP (mutant) + inhibitor<br />
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| **[[1njt]], [[1nju]], [[1nkk]], [[1nkm]] - CMVP (mutant) + peptide inhibitor<br />
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| *'''Varicella-Zoster virus protease'''
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| **[[1vzv]] - VZVP (mutant) – human herpes virus
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| *'''Equine infectious anemia virus protease'''
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| **[[2fmb]], [[1fmb]] – EIAVP (mutant) + inhibitor
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| *'''Hepatitis A virus protease'''
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| **[[2h9h]], [[2hal]] – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor
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| *'''Hepatitis C virus protease'''
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| **[[2o8m]] – HCVP (mutant)<br />
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| **[[2a4g]], [[2gvf]], [[2f9u]], [[2f9v]] – HCVP + peptide inhibitor<br />
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| *'''Orf 17'''
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| **[[3njq]] – hOrf 17 - human herpes virus 8
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| *'''Dengue virus protease'''
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| **[[3u1i]] – DvNs2b + peptide – Dengue virus<br />
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| **[[3u1j]] – DvNs2b + BPTI<br />
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| **[[2fom]] - DvNs2b/DvNs3<br />
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| **[[4m9f]], [[4m9i]], [[4m9k]], [[4m9m]], [[3lkw]] - DvNs2b/DvNs3 (mutant)<br />
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| **[[4m9t]] - DvNs2b/DvNs3 (mutant) + inhibitor<br />
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| **[[2jlq]] – DvNs3 residues 1646-2092 <br />
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| **[[2jlv]] – DvNs3 residues 1646-2092 + AMPPNP + RNA<br />
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| **[[2jlr]] – DvNs3 residues 1646-2092 + AMPPNP<br />
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| **[[2jls]] – DvNs3 residues 1646-2092 + ADP<br />
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| **[[2jlx]], [[2jly]], [[2jlz]] – DvNs3 residues 1646-2092 + ADP + RNA<br />
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| **[[2jlu]], [[2jlw]] – DvNs3 residues 1646-2092 + RNA<br />
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| **[[2vbc]], [[2whx]], [[2wzq]] – DvNs3 residues 1475-2092 + peptide inhibitor<br />
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| **[[2m9p]], [[2m9q]] – DvNs3 residues 1475-1648 + peptide inhibitor - NMR<br />
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| *'''Herpes simplex virus protease'''
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| **[[1at3]] – HSV II – human herpesvirus 2
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| *'''Foot-and-Mouth Disease virus protease'''
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| **[[2bhg]] – FMDV residues 1650-1857 (mutant) – Foot-and-mouth disease virus
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| *'''Infectious Bronchitis virus protease'''
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| **[[2q6d]] – IBV – infectious bronchitis virus <br />
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| **[[2q6f]] – IBV + inhibitor
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| *'''Yellowtail ascites virus protease'''
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| **[[4izj]], [[4izk]] – YAV Vp4 (mutant) – yellowtail ascites virus
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| *'''Pseudorabies virus protease'''
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| **[[4cx8]] – YAV – pseudorabies virus<br />
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| }}
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| ==References== | | ==References== |
| <references /> | | <references /> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
