6ht5: Difference between revisions
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==Oct4/Sox2:UTF1 structure== | |||
<StructureSection load='6ht5' size='340' side='right'caption='[[6ht5]], [[Resolution|resolution]] 3.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ht5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HT5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.451Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ht5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ht5 OCA], [https://pdbe.org/6ht5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ht5 RCSB], [https://www.ebi.ac.uk/pdbsum/6ht5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ht5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SOX2_MOUSE SOX2_MOUSE] Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).<ref>PMID:17097055</ref> <ref>PMID:22198669</ref> | |||
==See Also== | |||
*[[OCT4 and SOX2 transcription factors|OCT4 and SOX2 transcription factors]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Groves | </StructureSection> | ||
[[Category: Meusch | [[Category: Large Structures]] | ||
[[Category: Pogenberg | [[Category: Mus musculus]] | ||
[[Category: Wilmanns | [[Category: Groves M]] | ||
[[Category: Meusch D]] | |||
[[Category: Pogenberg V]] | |||
[[Category: Vahokoski J]] | |||
[[Category: Wilmanns M]] | |||
