2r2k: Difference between revisions

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[[Image:2r2k.jpg|left|200px]]


{{Structure
==Crystal structure of the complex of camel peptidoglycan recognition protein with disaccharide at 3.2A resolution==
|PDB= 2r2k |SIZE=350|CAPTION= <scene name='initialview01'>2r2k</scene>, resolution 3.25&Aring;
<StructureSection load='2r2k' size='340' side='right'caption='[[2r2k]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene>
<table><tr><td colspan='2'>[[2r2k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R2K FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2k OCA], [https://pdbe.org/2r2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r2k RCSB], [https://www.ebi.ac.uk/pdbsum/2r2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r2k ProSAT]</span></td></tr>
|RELATEDENTRY=[[1yck|1YCK]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2k OCA], [http://www.ebi.ac.uk/pdbsum/2r2k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r2k RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/PGRP1_CAMDR PGRP1_CAMDR] Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. May function in intracellular killing of bacteria (By similarity).
 
== Evolutionary Conservation ==
'''Crystal structure of the complex of camel peptidoglycan recognition protein with disaccharide at 3.2A resolution'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/2r2k_consurf.spt"</scriptWhenChecked>
2R2K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2K OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r2k ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Camelus dromedarius]]
[[Category: Camelus dromedarius]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Bhushan, A.]]
[[Category: Bhushan A]]
[[Category: Jain, R.]]
[[Category: Jain R]]
[[Category: Kaur, P.]]
[[Category: Kaur P]]
[[Category: Sharma, P.]]
[[Category: Sharma P]]
[[Category: Sharma, S.]]
[[Category: Sharma S]]
[[Category: Singh, N.]]
[[Category: Singh N]]
[[Category: Singh, T P.]]
[[Category: Singh TP]]
[[Category: antibiotic]]
[[Category: antimicrobial]]
[[Category: complex]]
[[Category: disaccharide]]
[[Category: immune response]]
[[Category: peptidoglycan recognition protein]]
[[Category: secreted]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:55:50 2008''
Retrieved from "https://proteopedia.org/2r2k"