6ijf: Difference between revisions
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New page: '''Unreleased structure''' The entry 6ijf is ON HOLD Authors: Fukuhara, S., Nakane, T., Yamashita, K., Ishii, R., Ishitani, R., Nureki, O. Description: Crystal structure of the type VI... |
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==Crystal structure of the type VI effector-immunity complex (Tae4-Tai4) from Agrobacterium tumefaciens== | |||
<StructureSection load='6ijf' size='340' side='right'caption='[[6ijf]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ijf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IJF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IJF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ijf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ijf OCA], [https://pdbe.org/6ijf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ijf RCSB], [https://www.ebi.ac.uk/pdbsum/6ijf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ijf ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A083ZID3_RHIRD A0A083ZID3_RHIRD] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The type VI secretion system (T6SS) comprises needle-shaped multisubunit complexes that play a role in the microbial defense systems of Gram-negative bacteria. Some Gram-negative bacteria harboring a T6SS deliver toxic effector proteins into the cytoplasm or periplasm of competing bacteria in order to lyse and kill them. To avoid self-cell disruption, these bacteria have cognate immunity proteins that inhibit their toxic effector proteins. T6SS amidase effector protein 4 (Tae4) and T6SS amidase immunity protein 4 (Tai4) are a representative of the toxic effector-immunity pairs of the T6SS. Here, the three-dimensional structures of Tai4 and the Tae4-Tai4 complex from Agrobacterium tumefaciens are reported at 1.55 and 1.9 A resolution, respectively. A structural comparison with other Tae4-Tai4 homologs revealed similarities and differences in the catalytic and inhibitory mechanisms among the Tae4 and Tai4 family proteins. | |||
Crystal structure of the Agrobacterium tumefaciens type VI effector-immunity complex.,Fukuhara S, Nakane T, Yamashita K, Ishii R, Ishitani R, Nureki O Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):810-816. doi:, 10.1107/S2053230X18016369. Epub 2018 Nov 30. PMID:30511676<ref>PMID:30511676</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 6ijf" style="background-color:#fffaf0;"></div> | ||
[[Category: Ishii | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Agrobacterium tumefaciens]] | ||
[[Category: Large Structures]] | |||
[[Category: Fukuhara S]] | |||
[[Category: Ishii R]] | |||
[[Category: Ishitani R]] | |||
[[Category: Nakane T]] | |||
[[Category: Nureki O]] | |||
[[Category: Yamashita K]] | |||
