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==Structure of wild type E. coli N-acetylneuraminic acid lyase in space group P21 crystal form II==
==Structure of wild type E. coli N-acetylneuraminic acid lyase in space group P21 crystal form II==
<StructureSection load='2ygy' size='340' side='right' caption='[[2ygy]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2ygy' size='340' side='right'caption='[[2ygy]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ygy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecobd Ecobd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YGY FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ygy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YGY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ygz|2ygz]], [[2wnq|2wnq]], [[2wkj|2wkj]], [[1fdz|1fdz]], [[1fdy|1fdy]], [[2wpb|2wpb]], [[2wo5|2wo5]], [[2wnn|2wnn]], [[1nal|1nal]], [[1hl2|1hl2]], [[2xfw|2xfw]], [[2wnz|2wnz]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylneuraminate_lyase N-acetylneuraminate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.3 4.1.3.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ygy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ygy OCA], [https://pdbe.org/2ygy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ygy RCSB], [https://www.ebi.ac.uk/pdbsum/2ygy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ygy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ygy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ygy OCA], [http://pdbe.org/2ygy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ygy RCSB], [http://www.ebi.ac.uk/pdbsum/2ygy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ygy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NANA_ECOLI NANA_ECOLI]] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.[HAMAP-Rule:MF_01237]  
[https://www.uniprot.org/uniprot/NANA_ECOLI NANA_ECOLI] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.[HAMAP-Rule:MF_01237]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 2ygy" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2ygy" style="background-color:#fffaf0;"></div>
==See Also==
*[[N-acetylneuraminate lyase 3D structures|N-acetylneuraminate lyase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecobd]]
[[Category: Large Structures]]
[[Category: N-acetylneuraminate lyase]]
[[Category: Berry A]]
[[Category: Berry, A]]
[[Category: Campeotto I]]
[[Category: Campeotto, I]]
[[Category: Nelson A]]
[[Category: Nelson, A]]
[[Category: Pearson AR]]
[[Category: Pearson, A R]]
[[Category: Phillips SEV]]
[[Category: Phillips, S E.V]]
[[Category: Directed evolution]]
[[Category: Lyase]]
[[Category: Protein engineering]]
[[Category: Substrate specificity]]
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