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==Crystal structure of GAR synthetase from Aquifex aeolicus in complex with ATP==
==Crystal structure of GAR synthetase from Aquifex aeolicus in complex with ATP==
<StructureSection load='2yw2' size='340' side='right' caption='[[2yw2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2yw2' size='340' side='right'caption='[[2yw2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2yw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YW2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2yw2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YW2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gso|1gso]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylamine--glycine_ligase Phosphoribosylamine--glycine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.13 6.3.4.13] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yw2 OCA], [https://pdbe.org/2yw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yw2 RCSB], [https://www.ebi.ac.uk/pdbsum/2yw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yw2 ProSAT], [https://www.topsan.org/Proteins/RSGI/2yw2 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yw2 OCA], [http://pdbe.org/2yw2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yw2 RCSB], [http://www.ebi.ac.uk/pdbsum/2yw2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yw2 ProSAT], [http://www.topsan.org/Proteins/RSGI/2yw2 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PUR2_AQUAE PUR2_AQUAE]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/2yw2_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yw/2yw2_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aquifex aeolicus huber and stetter 2001]]
[[Category: Aquifex aeolicus]]
[[Category: Phosphoribosylamine--glycine ligase]]
[[Category: Large Structures]]
[[Category: Baba, S]]
[[Category: Baba S]]
[[Category: Kanagawa, M]]
[[Category: Kanagawa M]]
[[Category: Kawai, G]]
[[Category: Kawai G]]
[[Category: Kuramitsu, S]]
[[Category: Kuramitsu S]]
[[Category: Structural genomic]]
[[Category: Sampei G]]
[[Category: Sampei, G]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: Atp binding]]
[[Category: Gar synthetase]]
[[Category: Glycinamide ribonucleotide synthetase]]
[[Category: Ligase]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Purine nucleotide biosynthetic pathway]]
[[Category: Rsgi]]

Latest revision as of 08:40, 30 October 2024

Crystal structure of GAR synthetase from Aquifex aeolicus in complex with ATP

2yw2, resolution 1.80Å

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