2zam: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:


==Crystal structure of mouse SKD1/VPS4B apo-form==
==Crystal structure of mouse SKD1/VPS4B apo-form==
<StructureSection load='2zam' size='340' side='right' caption='[[2zam]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='2zam' size='340' side='right'caption='[[2zam]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2zam]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZAM FirstGlance]. <br>
<table><tr><td colspan='2'>[[2zam]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZAM FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xwi|1xwi]], [[2zan|2zan]], [[2zao|2zao]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Skd1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zam OCA], [https://pdbe.org/2zam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zam RCSB], [https://www.ebi.ac.uk/pdbsum/2zam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zam ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zam OCA], [http://pdbe.org/2zam PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zam RCSB], [http://www.ebi.ac.uk/pdbsum/2zam PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zam ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VPS4B_MOUSE VPS4B_MOUSE]] Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (By similarity).<ref>PMID:10393249</ref> <ref>PMID:10679028</ref>
[https://www.uniprot.org/uniprot/VPS4B_MOUSE VPS4B_MOUSE] Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (By similarity).<ref>PMID:10393249</ref> <ref>PMID:10679028</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 29: Line 28:
</div>
</div>
<div class="pdbe-citations 2zam" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2zam" style="background-color:#fffaf0;"></div>
==See Also==
*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Inoue, M]]
[[Category: Mus musculus]]
[[Category: Kamikubo, H]]
[[Category: Inoue M]]
[[Category: Kataoka, M]]
[[Category: Kamikubo H]]
[[Category: Kato, R]]
[[Category: Kataoka M]]
[[Category: Kawasaki, M]]
[[Category: Kato R]]
[[Category: Wakatsuki, S]]
[[Category: Kawasaki M]]
[[Category: Yoshimori, T]]
[[Category: Wakatsuki S]]
[[Category: Aaa atpase]]
[[Category: Yoshimori T]]
[[Category: Atp-binding]]
[[Category: Membrane]]
[[Category: Nucleotide-binding]]
[[Category: Phosphorylation]]
[[Category: Protein transport]]
[[Category: Skd1]]
[[Category: Transport]]
[[Category: Vps4b]]
Retrieved from "https://proteopedia.org/2zam"