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[[Image:2reo.jpg|left|200px]]


{{Structure
==Crystal structure of human sulfotransferase 1C3 (Sult1C3) in complex with PAP==
|PDB= 2reo |SIZE=350|CAPTION= <scene name='initialview01'>2reo</scene>, resolution 2.651&Aring;
<StructureSection load='2reo' size='340' side='right'caption='[[2reo]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=A3P:ADENOSINE-3&#39;-5&#39;-DIPHOSPHATE'>A3P</scene>
<table><tr><td colspan='2'>[[2reo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2REO FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.651&#8491;</td></tr>
|GENE= SULT1C3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2reo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2reo OCA], [https://pdbe.org/2reo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2reo RCSB], [https://www.ebi.ac.uk/pdbsum/2reo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2reo ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2reo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2reo OCA], [http://www.ebi.ac.uk/pdbsum/2reo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2reo RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/ST1C3_HUMAN ST1C3_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.<ref>PMID:17936463</ref> <ref>PMID:17425406</ref>
 
== Evolutionary Conservation ==
'''Crystal structure of human sulfotransferase 1C3 (Sult1C3) in complex with PAP'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/2reo_consurf.spt"</scriptWhenChecked>
2REO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REO OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2reo ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev A]]
[[Category: Dong, A.]]
[[Category: Dong A]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Loppnau, P.]]
[[Category: Loppnau P]]
[[Category: Pan, P.]]
[[Category: Pan P]]
[[Category: Plotnikov, A N.]]
[[Category: Plotnikov AN]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Tempel W]]
[[Category: Tempel, W.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: alternative splicing]]
[[Category: cytoplasm]]
[[Category: pap]]
[[Category: polymorphism]]
[[Category: sgc]]
[[Category: structural genomics consortium]]
[[Category: sulfate conjugation]]
[[Category: sulfotransferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:59:34 2008''

Latest revision as of 11:55, 30 August 2023

Crystal structure of human sulfotransferase 1C3 (Sult1C3) in complex with PAP

2reo, resolution 2.65Å

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