3a2q: Difference between revisions

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==Structure of 6-aminohexanoate cyclic dimer hydrolase complexed with substrate==
==Structure of 6-aminohexanoate cyclic dimer hydrolase complexed with substrate==
<StructureSection load='3a2q' size='340' side='right' caption='[[3a2q]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3a2q' size='340' side='right'caption='[[3a2q]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3a2q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arthrobacter_sp._ki72 Arthrobacter sp. ki72]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A2Q FirstGlance]. <br>
<table><tr><td colspan='2'>[[3a2q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Paenarthrobacter_ureafaciens Paenarthrobacter ureafaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A2Q FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACA:6-AMINOHEXANOIC+ACID'>ACA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3a2p|3a2p]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACA:6-AMINOHEXANOIC+ACID'>ACA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-aminohexanoate-cyclic-dimer_hydrolase 6-aminohexanoate-cyclic-dimer hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.12 3.5.2.12] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a2q OCA], [https://pdbe.org/3a2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a2q RCSB], [https://www.ebi.ac.uk/pdbsum/3a2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a2q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a2q OCA], [http://pdbe.org/3a2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a2q RCSB], [http://www.ebi.ac.uk/pdbsum/3a2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a2q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NYLA_FLASK NYLA_FLASK]] Specifically catalyzes the hydrolysis of 6-aminohexanoic acid cyclic dimer (1,8-diazacyclotetradecane-2,9-dione) to form the linear dimer 6-aminohexanoyl-6-aminohexanoic acid. Is inactive on 6-aminohexanoic acid oligomers (degree of polymerization 2 to 6), various other cyclic amides, cyclic diamides, linear amides, oligopeptides, and casein. Allows the bacterium to grow on a medium containing 6-aminohexanoic acid cyclic dimer as the sole carbon and nitrogen sources.<ref>PMID:923591</ref>
[https://www.uniprot.org/uniprot/NYLA_FLASK NYLA_FLASK] Specifically catalyzes the hydrolysis of 6-aminohexanoic acid cyclic dimer (1,8-diazacyclotetradecane-2,9-dione) to form the linear dimer 6-aminohexanoyl-6-aminohexanoic acid. Is inactive on 6-aminohexanoic acid oligomers (degree of polymerization 2 to 6), various other cyclic amides, cyclic diamides, linear amides, oligopeptides, and casein. Allows the bacterium to grow on a medium containing 6-aminohexanoic acid cyclic dimer as the sole carbon and nitrogen sources.<ref>PMID:923591</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[6-aminohexanoate-dimer hydrolase|6-aminohexanoate-dimer hydrolase]]
*[[6-aminohexanoate-dimer hydrolase 3D structures|6-aminohexanoate-dimer hydrolase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 6-aminohexanoate-cyclic-dimer hydrolase]]
[[Category: Large Structures]]
[[Category: Arthrobacter sp. ki72]]
[[Category: Paenarthrobacter ureafaciens]]
[[Category: Shibata, N]]
[[Category: Shibata N]]
[[Category: Alpha/beta fold]]
[[Category: Hydrolase]]
[[Category: Nylon degradation]]
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