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==Crystal structure of Proliferating cellular nuclear antigen 1 and Short peptide from human P21==
==Crystal structure of Proliferating cellular nuclear antigen 1 and Short peptide from human P21==
<StructureSection load='2zvv' size='340' side='right' caption='[[2zvv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2zvv' size='340' side='right'caption='[[2zvv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2zvv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZVV FirstGlance]. <br>
<table><tr><td colspan='2'>[[2zvv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZVV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zvw|2zvw]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvv OCA], [http://pdbe.org/2zvv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zvv RCSB], [http://www.ebi.ac.uk/pdbsum/2zvv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvv OCA], [https://pdbe.org/2zvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zvv RCSB], [https://www.ebi.ac.uk/pdbsum/2zvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PCNA1_ARATH PCNA1_ARATH]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similarity).[HAMAP-Rule:MF_00317] [[http://www.uniprot.org/uniprot/CDN1A_HUMAN CDN1A_HUMAN]] May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.<ref>PMID:8242751</ref> <ref>PMID:9106657</ref> 
[https://www.uniprot.org/uniprot/PCNA1_ARATH PCNA1_ARATH] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similarity).[HAMAP-Rule:MF_00317]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Proliferating Cell Nuclear Antigen|Proliferating Cell Nuclear Antigen]]
*[[Proliferating cell nuclear antigen 3D structures|Proliferating cell nuclear antigen 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arath]]
[[Category: Arabidopsis thaliana]]
[[Category: Morikawa, K]]
[[Category: Homo sapiens]]
[[Category: Oyama, T]]
[[Category: Large Structures]]
[[Category: Strzalka, W]]
[[Category: Morikawa K]]
[[Category: Tori, K]]
[[Category: Oyama T]]
[[Category: Dna binding protein]]
[[Category: Strzalka W]]
[[Category: Dna replication]]
[[Category: Tori K]]
[[Category: Dna-binding]]
[[Category: Nucleus]]
[[Category: Protein-peptide complex]]
Retrieved from "https://proteopedia.org/2zvv"