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==Integrated structural and functional model of the human ESCRT-II complex==
==Integrated structural and functional model of the human ESCRT-II complex==
<StructureSection load='2zme' size='340' side='right' caption='[[2zme]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='2zme' size='340' side='right'caption='[[2zme]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2zme]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZME FirstGlance]. <br>
<table><tr><td colspan='2'>[[2zme]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZME FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3cuq|3cuq]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SNF8, EAP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), VPS36, C13orf9, EAP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), VPS25, DERP9, EAP20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zme OCA], [https://pdbe.org/2zme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zme RCSB], [https://www.ebi.ac.uk/pdbsum/2zme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zme ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zme OCA], [http://pdbe.org/2zme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zme RCSB], [http://www.ebi.ac.uk/pdbsum/2zme PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zme ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SNF8_HUMAN SNF8_HUMAN]] Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.<ref>PMID:17959629</ref> <ref>PMID:17714434</ref> <ref>PMID:18031739</ref> [[http://www.uniprot.org/uniprot/VPS25_HUMAN VPS25_HUMAN]] Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.<ref>PMID:18723511</ref>  [[http://www.uniprot.org/uniprot/VPS36_HUMAN VPS36_HUMAN]] Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.<ref>PMID:15755741</ref> 
[https://www.uniprot.org/uniprot/SNF8_HUMAN SNF8_HUMAN] Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.<ref>PMID:17959629</ref> <ref>PMID:17714434</ref> <ref>PMID:18031739</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 2zme" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2zme" style="background-color:#fffaf0;"></div>
==See Also==
*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Hurley, J H]]
[[Category: Large Structures]]
[[Category: Im, Y J]]
[[Category: Hurley JH]]
[[Category: Endosome]]
[[Category: Im YJ]]
[[Category: Escrt]]
[[Category: Lipid-binding]]
[[Category: Mbv]]
[[Category: Nucleus]]
[[Category: Protein transport]]
[[Category: Sorting]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transport]]
[[Category: Vp]]

Latest revision as of 13:43, 1 November 2023

Integrated structural and functional model of the human ESCRT-II complex

2zme, resolution 2.90Å

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