Insertase: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='4utq' size='340' side='right' caption='Cryo EM structure of E. coli insertase (grey) complex with membrane domain of ATP synthase (green) PDB code 4utq.' scene... |
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<StructureSection load='4utq' size='340' side='right' caption='Cryo EM structure of E. coli insertase (cyan) complex with membrane domain of ATP synthase (green) PDB code [[4utq]].' scene='79/799601/Cv/1'> | |||
<StructureSection load='4utq' size='340' side='right' caption='Cryo EM structure of E. coli insertase ( | |||
'''Insertase''' (Ins) catalyzes the insertion of proteins into the prokaryotic plasma membrane. Ins interacts with its substrate in a groove-like structure at an ampiphilic protein-lipid interface allowing the transmembrane segments of the substrate to slide into the lipid bilayer<ref>PMID:27879020</ref>. | '''Insertase''' (Ins) catalyzes the insertion of proteins into the prokaryotic plasma membrane. Ins interacts with its substrate in a groove-like structure at an ampiphilic protein-lipid interface allowing the transmembrane segments of the substrate to slide into the lipid bilayer<ref>PMID:27879020</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
E. Coli Ins (YidC) contains 6 transmembrane segments. <scene name='79/799601/Cv/2'>Two of these segments was found to interact with a helical segments of a protein which is a candidate for insertion into a plasma membrane</scene><ref>PMID:18996118</ref>. | |||
</StructureSection> | </StructureSection> | ||
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[[5m5h]], [[3wvf]] - EcIns YidC - ''Escherichia coli'' - Cryo EM<br /> | [[5m5h]], [[3wvf]] - EcIns YidC - ''Escherichia coli'' - Cryo EM<br /> | ||
[[6al2]] - EcIns YidC <br /> | |||
[[3bs6]] - EcIns YidC periplasmic domain<br /> | [[3bs6]] - EcIns YidC periplasmic domain<br /> | ||
[[4utq]] - EcIns YidC + ATP synthase subunit C - Cryo EM<br /> | [[4utq]] - EcIns YidC + ATP synthase subunit C - Cryo EM<br /> | ||
[[5mg3]] - EcIns YidC + SECY + SECE + SECG + SECD + SECF - Cryo EM<br /> | |||
[[3wo7]], [[3wo6]] - Ins YidC - ''Bacillus halodurans''<br /> | [[3wo7]], [[3wo6]] - Ins YidC - ''Bacillus halodurans''<br /> | ||
[[4c4v]] - EcIns BamA reasidues 344-808<br /> | [[4c4v]] - EcIns BamA reasidues 344-808<br /> | ||
[[6fsu]] - EcIns BamA reasidues 421-810<br /> | |||
[[5ekq]] - Ins BamA + BamC + BamD + BamE <br /> | [[5ekq]] - Ins BamA + BamC + BamD + BamE <br /> | ||
[[4k3b]] - Ins BamA - ''Neisseria gonorrhoeae'' <br /> | [[4k3b]] - Ins BamA - ''Neisseria gonorrhoeae'' <br /> | ||
[[4k3c]] - Ins BamA - ''Haemophilus Ducreyi''<br /> | [[4k3c]] - Ins BamA - ''Haemophilus Ducreyi''<br /> | ||
[[5y82]], [[5y83]] - | [[5y82]], [[5y83]] - TmIns YidC (mutant) - ''Thermotoga maritima''<br /> | ||
[[6y86]] - TmIns YidC <br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
