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==Crystal structure of Actin capping protein==
==Crystal structure of Actin capping protein==
<StructureSection load='3aa7' size='340' side='right' caption='[[3aa7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3aa7' size='340' side='right'caption='[[3aa7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3aa7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AA7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AA7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3aa7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AA7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1izn|1izn]], [[3aa0|3aa0]], [[3aa1|3aa1]], [[3aa6|3aa6]], [[3aaa|3aaa]], [[3aae|3aae]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAPZA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK]), CAPZB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aa7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aa7 OCA], [https://pdbe.org/3aa7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aa7 RCSB], [https://www.ebi.ac.uk/pdbsum/3aa7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aa7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aa7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aa7 OCA], [http://pdbe.org/3aa7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3aa7 RCSB], [http://www.ebi.ac.uk/pdbsum/3aa7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3aa7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CAZA1_CHICK CAZA1_CHICK]] F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line. [[http://www.uniprot.org/uniprot/CAPZB_CHICK CAPZB_CHICK]] F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the regulation of cell morphology and cytoskeletal organization.  
[https://www.uniprot.org/uniprot/CAZA1_CHICK CAZA1_CHICK] F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Actinin|Actinin]]
*[[Actinin 3D structures|Actinin 3D structures]]
*[[F-actin capping protein|F-actin capping protein]]
*[[F-actin capping protein|F-actin capping protein]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chick]]
[[Category: Gallus gallus]]
[[Category: Kitazawa, M]]
[[Category: Large Structures]]
[[Category: Maeda, Y]]
[[Category: Kitazawa M]]
[[Category: Minakata, S]]
[[Category: Maeda Y]]
[[Category: Narita, A]]
[[Category: Minakata S]]
[[Category: Nitanai, Y]]
[[Category: Narita A]]
[[Category: Takeda, S]]
[[Category: Nitanai Y]]
[[Category: Yamakuni, T]]
[[Category: Takeda S]]
[[Category: Actin capping]]
[[Category: Yamakuni T]]
[[Category: Actin capping protein]]
[[Category: Actin-binding]]
[[Category: Barbed end regulation]]
[[Category: Carmil family protein]]
[[Category: Cell motility]]
[[Category: Conformational change]]
[[Category: Cytoskeleton]]
[[Category: Protein binding]]
Retrieved from "https://proteopedia.org/3aa7"