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==Crystal structure of Actin capping protein in complex with the Cp-binding motif derived from CD2AP==
==Crystal structure of Actin capping protein in complex with the Cp-binding motif derived from CD2AP==
<StructureSection load='3aa6' size='340' side='right' caption='[[3aa6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3aa6' size='340' side='right'caption='[[3aa6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3aa6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AA6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AA6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3aa6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AA6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1izn|1izn]], [[3aa0|3aa0]], [[3aa1|3aa1]], [[3aa7|3aa7]], [[3aaa|3aaa]], [[3aae|3aae]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAPZA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK]), CAPZB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aa6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aa6 OCA], [https://pdbe.org/3aa6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aa6 RCSB], [https://www.ebi.ac.uk/pdbsum/3aa6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aa6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aa6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aa6 OCA], [http://pdbe.org/3aa6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3aa6 RCSB], [http://www.ebi.ac.uk/pdbsum/3aa6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3aa6 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/CD2AP_HUMAN CD2AP_HUMAN]] Defects in CD2AP are the cause of susceptibility to focal segmental glomerulosclerosis type 3 (FSGS3) [MIM:[http://omim.org/entry/607832 607832]]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.<ref>PMID:12764198</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CAZA1_CHICK CAZA1_CHICK]] F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line. [[http://www.uniprot.org/uniprot/CD2AP_HUMAN CD2AP_HUMAN]] Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.<ref>PMID:15800069</ref>  [[http://www.uniprot.org/uniprot/CAPZB_CHICK CAPZB_CHICK]] F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the regulation of cell morphology and cytoskeletal organization.  
[https://www.uniprot.org/uniprot/CAZA1_CHICK CAZA1_CHICK] F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Actinin|Actinin]]
*[[Actinin 3D structures|Actinin 3D structures]]
*[[CD2-associated protein|CD2-associated protein]]
*[[CD2-associated protein 3D structures|CD2-associated protein 3D structures]]
*[[F-actin capping protein|F-actin capping protein]]
*[[F-actin capping protein|F-actin capping protein]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chick]]
[[Category: Gallus gallus]]
[[Category: Kitazawa, M]]
[[Category: Homo sapiens]]
[[Category: Maeda, Y]]
[[Category: Large Structures]]
[[Category: Minakata, S]]
[[Category: Kitazawa M]]
[[Category: Narita, A]]
[[Category: Maeda Y]]
[[Category: Nitanai, Y]]
[[Category: Minakata S]]
[[Category: Takeda, S]]
[[Category: Narita A]]
[[Category: Yamakuni, T]]
[[Category: Nitanai Y]]
[[Category: Actin capping]]
[[Category: Takeda S]]
[[Category: Actin capping protein]]
[[Category: Yamakuni T]]
[[Category: Actin-binding]]
[[Category: Barbed end regulation]]
[[Category: Carmil family protein]]
[[Category: Cd2ap]]
[[Category: Cell cycle]]
[[Category: Cell division]]
[[Category: Cell motility]]
[[Category: Cell projection]]
[[Category: Conformational change]]
[[Category: Cytoskeleton]]
[[Category: Mitosis]]
[[Category: Protein binding]]
[[Category: Sh3 domain]]
[[Category: Sh3-binding]]
Retrieved from "https://proteopedia.org/3aa6"