6gk2: Difference between revisions

<StructureSection load='6gk2' size='340' side='right' caption='[[6gk2]], [[Resolution|resolution]] 4.90&Aring;' scene=''>

<table><tr><td colspan='2'>[[6gk2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GK2 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gk2 OCA], [http://pdbe.org/6gk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gk2 RCSB], [http://www.ebi.ac.uk/pdbsum/6gk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gk2 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/BCL10_HUMAN BCL10_HUMAN]] A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.  Defects in BCL10 are involved in various types of cancer.  The gene represented in this entry may be involved in disease pathogenesis. [[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.  

[[http://www.uniprot.org/uniprot/BCL10_HUMAN BCL10_HUMAN]] Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.<ref>PMID:18264101</ref> [[http://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref> <ref>PMID:14695475</ref> <ref>PMID:18264101</ref> 

</StructureSection>

[[Category: Desfosses, A]]

[[Category: Gutsche, I]]

[[Category: Hopfner, K P]]

[[Category: Lammens, K]]

[[Category: Schlauderer, F]]

[[Category: Autoimmune disease]]

[[Category: Bcl10]]

[[Category: Malt1]]