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==Structure of dbOphMA in Complex with SAH and Methylated Peptide==
==Structure of dbOphMA in Complex with SAH and Methylated Peptide==
<StructureSection load='6mjg' size='340' side='right' caption='[[6mjg]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
<StructureSection load='6mjg' size='340' side='right'caption='[[6mjg]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6mjg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dendrothele_bispora_cbs_962.96 Dendrothele bispora cbs 962.96]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MJG FirstGlance]. <br>
<table><tr><td colspan='2'>[[6mjg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendrothele_bispora_CBS_962.96 Dendrothele bispora CBS 962.96]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MJG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.123&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=IML:N-METHYL-ISOLEUCINE'>IML</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IML:N-METHYL-ISOLEUCINE'>IML</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjg OCA], [http://pdbe.org/6mjg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mjg RCSB], [http://www.ebi.ac.uk/pdbsum/6mjg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjg OCA], [https://pdbe.org/6mjg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mjg RCSB], [https://www.ebi.ac.uk/pdbsum/6mjg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DBIMA_DENBC DBIMA_DENBC] Fusion protein of the methyltransferase dbiM and the dendrothelin core peptide; part of the gene cluster that mediates the biosynthesis of dendrothelin A, a highly methylated cyclic dodecapeptide showing slight nematodicidal activity (PubMed:30204409, PubMed:33574430). Dendrothelin A derives from the C-terminus of the dbiMA protein, and it is the dbiMA protein that methylates its own C-terminus using S-adenosyl methionine (SAM) (PubMed:30204409, PubMed:33574430). The C-terminus is subsequently cleaved off and macrocyclized by the prolyloligopeptidase dbiP to give the final product (PubMed:30204409, PubMed:33574430).<ref>PMID:30204409</ref> <ref>PMID:33574430</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dendrothele bispora cbs 962 96]]
[[Category: Dendrothele bispora CBS 962 96]]
[[Category: Nair, S K]]
[[Category: Large Structures]]
[[Category: Ongpipattanakul, C]]
[[Category: Nair SK]]
[[Category: Biosynthetic protein]]
[[Category: Ongpipattanakul C]]
[[Category: Borosin]]
[[Category: Methyltransferase]]
Retrieved from "https://proteopedia.org/6mjg"