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==Crystal structure of the fructose-1,6-bisphosphatase GlpX from E.coli in complex with inorganic phosphate==
==Crystal structure of the fructose-1,6-bisphosphatase GlpX from E.coli in complex with inorganic phosphate==
<StructureSection load='3big' size='340' side='right' caption='[[3big]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='3big' size='340' side='right'caption='[[3big]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3big]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BIG FirstGlance]. <br>
<table><tr><td colspan='2'>[[3big]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BIG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bih|3bih]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">glpX, b3925, JW3896 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3big FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3big OCA], [https://pdbe.org/3big PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3big RCSB], [https://www.ebi.ac.uk/pdbsum/3big PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3big ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3big FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3big OCA], [http://pdbe.org/3big PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3big RCSB], [http://www.ebi.ac.uk/pdbsum/3big PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3big ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GLPX_ECOLI GLPX_ECOLI]] Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Is likely to be involved in gluconeogenesis during growth on glycerol. Also displays a low activity toward glucose 1,6-bisphosphate, and no activity against ribulose 1,5-bisphosphate, fructose 2,6-bisphosphate, or fructose 1-phosphate.<ref>PMID:10986273</ref> <ref>PMID:19073594</ref>
[https://www.uniprot.org/uniprot/GLPX_ECOLI GLPX_ECOLI] Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Is likely to be involved in gluconeogenesis during growth on glycerol. Also displays a low activity toward glucose 1,6-bisphosphate, and no activity against ribulose 1,5-bisphosphate, fructose 2,6-bisphosphate, or fructose 1-phosphate.<ref>PMID:10986273</ref> <ref>PMID:19073594</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Fructose-1%2C6-bisphosphatase|Fructose-1%2C6-bisphosphatase]]
*[[Fructose-1%2C6-bisphosphatase 3D structures|Fructose-1%2C6-bisphosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli K-12]]
[[Category: Fructose-bisphosphatase]]
[[Category: Large Structures]]
[[Category: Brown, G]]
[[Category: Brown G]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Lunin, V V]]
[[Category: Lunin VV]]
[[Category: Savchenko, A]]
[[Category: Savchenko A]]
[[Category: Skarina, T]]
[[Category: Skarina T]]
[[Category: Yakunin, A F]]
[[Category: Yakunin AF]]
[[Category: 6-bisphosphatase]]
[[Category: Carbohydrate metabolism]]
[[Category: Glpx]]
[[Category: Hydrolase]]
[[Category: Manganese]]
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