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==Structure of ePepN E298A mutant in complex with Puromycin==
==Structure of ePepN E298A mutant in complex with Puromycin==
<StructureSection load='5yo1' size='340' side='right' caption='[[5yo1]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='5yo1' size='340' side='right'caption='[[5yo1]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5yo1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YO1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5yo1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YO1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PUY:PUROMYCIN'>PUY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane_alanyl_aminopeptidase Membrane alanyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.2 3.4.11.2] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PUY:PUROMYCIN'>PUY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yo1 OCA], [http://pdbe.org/5yo1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yo1 RCSB], [http://www.ebi.ac.uk/pdbsum/5yo1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yo1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yo1 OCA], [https://pdbe.org/5yo1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yo1 RCSB], [https://www.ebi.ac.uk/pdbsum/5yo1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yo1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AMPN_ECOLI AMPN_ECOLI]] Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.  
[https://www.uniprot.org/uniprot/AMPN_ECOLI AMPN_ECOLI] Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.
 
==See Also==
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Membrane alanyl aminopeptidase]]
[[Category: Escherichia coli K-12]]
[[Category: Addlagatta, A]]
[[Category: Large Structures]]
[[Category: Ganji, R J]]
[[Category: Addlagatta A]]
[[Category: Marapaka, A K]]
[[Category: Ganji RJ]]
[[Category: Reddi, R]]
[[Category: Marapaka AK]]
[[Category: Hydrolase]]
[[Category: Reddi R]]
[[Category: M1 class aminopeptidase]]

Latest revision as of 08:33, 22 November 2023

Structure of ePepN E298A mutant in complex with Puromycin

5yo1, resolution 2.50Å

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