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[[Image:2v7r.jpg|left|200px]]


{{Structure
==Crystal structure of a human tRNAGly microhelix at 1.2 Angstrom resolution==
|PDB= 2v7r |SIZE=350|CAPTION= <scene name='initialview01'>2v7r</scene>, resolution 1.20&Aring;
<StructureSection load='2v7r' size='340' side='right'caption='[[2v7r]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
<table><tr><td colspan='2'>[[2v7r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V7R FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
|GENE=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7r OCA], [https://pdbe.org/2v7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v7r RCSB], [https://www.ebi.ac.uk/pdbsum/2v7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v7r ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
<div style="background-color:#fffaf0;">
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7r OCA], [http://www.ebi.ac.uk/pdbsum/2v7r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v7r RCSB]</span>
== Publication Abstract from PubMed ==
}}
 
'''CRYSTAL STRUCTURE OF A HUMAN TRNAGLY MICROHELIX AT 1.2 ANGSTROM RESOLUTION'''
 
 
==Overview==
The tRNA(Gly)/glycyl-tRNA synthetase (GlyRS) system belongs to the so-called 'class II aminoacyl-tRNA synthetase system' in which tRNA identity elements are assured by rather few and simple determinants mostly located in the tRNA acceptor stem. Regarding evolutionary aspects, the tRNA(Gly)/GlyRS system is a special case. There exist two different types of GlyRS, namely an archaebacterial/human type and a eubacterial type reflecting an evolutionary divergence within this system. Here we report the crystal structure of a human tRNA(Gly) acceptor stem microhelix at 1.2A resolution. The local geometric parameters of the microhelix and the water network surrounding the RNA are presented. The structure complements the previously published Escherichia coli tRNA(Gly) aminoacyl stem structure.
The tRNA(Gly)/glycyl-tRNA synthetase (GlyRS) system belongs to the so-called 'class II aminoacyl-tRNA synthetase system' in which tRNA identity elements are assured by rather few and simple determinants mostly located in the tRNA acceptor stem. Regarding evolutionary aspects, the tRNA(Gly)/GlyRS system is a special case. There exist two different types of GlyRS, namely an archaebacterial/human type and a eubacterial type reflecting an evolutionary divergence within this system. Here we report the crystal structure of a human tRNA(Gly) acceptor stem microhelix at 1.2A resolution. The local geometric parameters of the microhelix and the water network surrounding the RNA are presented. The structure complements the previously published Escherichia coli tRNA(Gly) aminoacyl stem structure.


==About this Structure==
Crystal structure of a human tRNA(Gly) microhelix at 1.2A resolution.,Forster C, Mankowska M, Furste JP, Perbandt M, Betzel Ch, Erdmann VA Biochem Biophys Res Commun. 2008 Apr 18;368(4):996-1001. Epub 2008 Feb 13. PMID:18279665<ref>PMID:18279665</ref>
2V7R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7R OCA].
 
==Reference==
Crystal structure of a human tRNA(Gly) microhelix at 1.2A resolution., Forster C, Mankowska M, Furste JP, Perbandt M, Betzel Ch, Erdmann VA, Biochem Biophys Res Commun. 2008 Apr 18;368(4):996-1001. Epub 2008 Feb 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18279665 18279665]
[[Category: Single protein]]
[[Category: Betzel, C.]]
[[Category: Erdmann, V A.]]
[[Category: Foerster, C.]]
[[Category: Fuerste, J P.]]
[[Category: Mankowska, M.]]
[[Category: Perbandt, M.]]
[[Category: acceptor stem]]
[[Category: glycine]]
[[Category: hydration]]
[[Category: identity]]
[[Category: microhelix]]
[[Category: rna]]
[[Category: trna]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:09:19 2008''
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2v7r" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Betzel C]]
[[Category: Erdmann VA]]
[[Category: Foerster C]]
[[Category: Fuerste JP]]
[[Category: Mankowska M]]
[[Category: Perbandt M]]

Latest revision as of 09:56, 9 May 2024

Crystal structure of a human tRNAGly microhelix at 1.2 Angstrom resolution

2v7r, resolution 1.20Å

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