3cld: Difference between revisions

<StructureSection load='3cld' size='340' side='right'caption='[[3cld]], [[Resolution|resolution]] 2.84&Aring;' scene=''>

<table><tr><td colspan='2'>[[3cld]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CLD FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GW6:(6ALPHA,11ALPHA,14BETA,16ALPHA,17ALPHA)-6,9-DIFLUORO-17-{[(FLUOROMETHYL)SULFANYL]CARBONYL}-11-HYDROXY-16-METHYL-3-OXOANDROSTA-1,4-DIEN-17-YL+FURAN-2-CARBOXYLATE'>GW6</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cld OCA], [https://pdbe.org/3cld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cld RCSB], [https://www.ebi.ac.uk/pdbsum/3cld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cld ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[https://omim.org/entry/138040 138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>  

[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>  

*[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]]

[[Category: Biggadike KB]]

[[Category: Bledsoe RK]]

[[Category: Hassell AM]]

[[Category: McLay I]]

[[Category: Shewchuk LM]]

[[Category: Stewart E]]