2vdv: Difference between revisions

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[[Image:2vdv.jpg|left|200px]]


{{Structure
==Structure of trm8, m7G methylation enzyme==
|PDB= 2vdv |SIZE=350|CAPTION= <scene name='initialview01'>2vdv</scene>, resolution 2.3&Aring;
<StructureSection load='2vdv' size='340' side='right'caption='[[2vdv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Sam+Binding+Site+For+Chain+E'>AC1</scene> and <scene name='pdbsite=AC2:Sam+Binding+Site+For+Chain+F'>AC2</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>
<table><tr><td colspan='2'>[[2vdv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VDV FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(guanine-N(7)-)-methyltransferase tRNA (guanine-N(7)-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.33 2.1.1.33] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vdv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vdv OCA], [https://pdbe.org/2vdv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vdv RCSB], [https://www.ebi.ac.uk/pdbsum/2vdv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vdv ProSAT]</span></td></tr>
|RELATEDENTRY=[[2vdu|2VDU]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vdv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vdv OCA], [http://www.ebi.ac.uk/pdbsum/2vdv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vdv RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/TRMB_YEAST TRMB_YEAST] Methyltransferase that catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity.[HAMAP-Rule:MF_03055]<ref>PMID:16387656</ref> <ref>PMID:17382321</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/2vdv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vdv ConSurf].
<div style="clear:both"></div>


'''STRUCTURE OF TRM8, M7G METHYLATION ENZYME'''
==See Also==
 
*[[TRNA methyltransferase 3D structures|TRNA methyltransferase 3D structures]]
 
== References ==
==About this Structure==
<references/>
2VDV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDV OCA].
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Blondeau K]]
[[Category: tRNA (guanine-N(7)-)-methyltransferase]]
[[Category: Chaillet M]]
[[Category: Blondeau, K.]]
[[Category: Durand D]]
[[Category: Chaillet, M.]]
[[Category: Leulliot N]]
[[Category: Durand, D.]]
[[Category: Ulryck N]]
[[Category: Leulliot, N.]]
[[Category: Van Tilbeurgh H]]
[[Category: Tilbeurgh, H Van.]]
[[Category: Ulryck, N.]]
[[Category: m7g]]
[[Category: methyltransferase]]
[[Category: phosphorylation]]
[[Category: s-adenosyl-l-methionine]]
[[Category: spout mt]]
[[Category: transferase]]
[[Category: trna]]
[[Category: trna processing]]
 
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Retrieved from "https://proteopedia.org/2vdv"