6iqk: Difference between revisions
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==crystal structure of Arabidopsis thaliana Profilin 3== | |||
<StructureSection load='6iqk' size='340' side='right'caption='[[6iqk]], [[Resolution|resolution]] 3.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6iqk]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IQK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iqk OCA], [https://pdbe.org/6iqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iqk RCSB], [https://www.ebi.ac.uk/pdbsum/6iqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iqk ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PRF3_ARATH PRF3_ARATH] Binds to actin monomers and regulates the organization of the actin cytoskeleton (PubMed:23052593, PubMed:29861135). Can increase the critical concentration (Cc) of actin assembly in vitro (PubMed:23052593). Acts as downstream effector of the hydrogen sulfide signaling to regulate the assembly and depolymerization of F-actin (PubMed:25652660). At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (Probable). Binding to the poly-proline motif of formin induces oligomerization of PRF3 (PubMed:29861135). PRF3 oligomers inhibit formin-mediated actin assembly to modulate plant immunity triggered by pathogen-associated molecular patterns (PAMPs) (PubMed:29861135).<ref>PMID:23052593</ref> <ref>PMID:25652660</ref> <ref>PMID:29861135</ref> <ref>PMID:29861135</ref> | |||
==See Also== | |||
*[[Profilin 3D Structures|Profilin 3D Structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Gao | __TOC__ | ||
[[Category: Qiao | </StructureSection> | ||
[[Category: Arabidopsis thaliana]] | |||
[[Category: Large Structures]] | |||
[[Category: Gao Y]] | |||
[[Category: Qiao Z]] | |||
Latest revision as of 10:34, 27 March 2024
crystal structure of Arabidopsis thaliana Profilin 3
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