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==Structure of mechanically activated ion channel OSCA1.2 in LMNG==
==Structure of mechanically activated ion channel OSCA1.2 in LMNG==
<StructureSection load='6mgw' size='340' side='right' caption='[[6mgw]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<SX load='6mgw' size='340' side='right' viewer='molstar' caption='[[6mgw]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6mgw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MGW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MGW FirstGlance]. <br>
<table><tr><td colspan='2'>[[6mgw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MGW FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6mgv|6mgv]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mgw OCA], [http://pdbe.org/6mgw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mgw RCSB], [http://www.ebi.ac.uk/pdbsum/6mgw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mgw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mgw OCA], [https://pdbe.org/6mgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mgw RCSB], [https://www.ebi.ac.uk/pdbsum/6mgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mgw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CSC1_ARATH CSC1_ARATH]] Acts as an osmosensitive calcium-permeable cation channel. Specifically conducts cations including Ca(2+), K(+) and Na(+) in vitro. Inactivation or closure of the channel is calcium-dependent.<ref>PMID:24503647</ref>
[https://www.uniprot.org/uniprot/CSC1_ARATH CSC1_ARATH] Acts as an osmosensitive calcium-permeable cation channel. Specifically conducts cations including Ca(2+), K(+) and Na(+) in vitro. Inactivation or closure of the channel is calcium-dependent.<ref>PMID:24503647</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Mechanically activated ion channels underlie touch, hearing, shear-stress sensing, and response to turgor pressure. OSCA/TMEM63s are a newly-identified family of eukaryotic mechanically activated ion channels opened by membrane tension. The structural underpinnings of OSCA/TMEM63 function are not explored. Here, we elucidate high resolution cryo-electron microscopy structures of OSCA1.2, revealing a dimeric architecture containing eleven transmembrane helices per subunit and surprising topological similarities to TMEM16 proteins. We locate the ion permeation pathway within each subunit by demonstrating that a conserved acidic residue is a determinant of channel conductance. Molecular dynamics simulations reveal membrane interactions, suggesting the role of lipids in OSCA1.2 gating. These results lay a foundation to decipher how the structural organization of OSCA/TMEM63 is suited for their roles as MA ion channels.


Cryo-EM structure of the mechanically activated ion channel OSCA1.2.,Jojoa Cruz S, Saotome K, Murthy SE, Tsui CCA, Sansom MS, Patapoutian A, Ward AB Elife. 2018 Nov 1;7. pii: 41845. doi: 10.7554/eLife.41845. PMID:30382939<ref>PMID:30382939</ref>
==See Also==
 
*[[Ion channels 3D structures|Ion channels 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6mgw" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Jojoa-Cruz, S]]
[[Category: Arabidopsis thaliana]]
[[Category: Patapoutian, A]]
[[Category: Large Structures]]
[[Category: Saotome, K]]
[[Category: Jojoa-Cruz S]]
[[Category: Ward, A B]]
[[Category: Patapoutian A]]
[[Category: Mechanically activated ion channel]]
[[Category: Saotome K]]
[[Category: Membrane protein]]
[[Category: Ward AB]]
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