2voe: Difference between revisions

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[[Image:2voe.jpg|left|200px]]


{{Structure
==Crystal structure of Rv2780 from M. tuberculosis H37Rv==
|PDB= 2voe |SIZE=350|CAPTION= <scene name='initialview01'>2voe</scene>, resolution 2.60&Aring;
<StructureSection load='2voe' size='340' side='right'caption='[[2voe]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2voe]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOE FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_dehydrogenase Alanine dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.1.1 1.4.1.1] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2voe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voe OCA], [https://pdbe.org/2voe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2voe RCSB], [https://www.ebi.ac.uk/pdbsum/2voe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2voe ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=[[2vhv|2VHV]], [[2vhw|2VHW]], [[2vhx|2VHX]], [[2vhy|2VHY]], [[2vhz|2VHZ]], [[2voj|2VOJ]]
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2voe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voe OCA], [http://www.ebi.ac.uk/pdbsum/2voe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2voe RCSB]</span>
[https://www.uniprot.org/uniprot/DHA_MYCTU DHA_MYCTU] Catalyzes the reversible reductive amination of pyruvate to L-alanine. However, since the physiological environment of M.tuberculosis has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-alanine. May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.<ref>PMID:10527947</ref>
}}
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
'''CRYSTAL STRUCTURE OF RV2780 FROM M. TUBERCULOSIS H37RV'''
Check<jmol>
 
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2voe_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
2VOE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOE OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Alanine dehydrogenase]]
  </jmolCheckbox>
[[Category: Mycobacterium tuberculosis]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2voe ConSurf].
[[Category: Single protein]]
<div style="clear:both"></div>
[[Category: Ramachandran, R.]]
== References ==
[[Category: Tripathi, S M.]]
<references/>
[[Category: alanine dehydrogenase]]
__TOC__
[[Category: nad]]
</StructureSection>
[[Category: oxidoreductase]]
[[Category: Large Structures]]
[[Category: pyruvate]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: rv2780]]
[[Category: Ramachandran R]]
[[Category: secreted]]
[[Category: Tripathi SM]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:13:49 2008''

Latest revision as of 10:02, 9 May 2024

Crystal structure of Rv2780 from M. tuberculosis H37Rv

2voe, resolution 2.60Å

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