2voj: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(13 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2voj.jpg|left|200px]]


{{Structure
==Ternary complex of M. tuberculosis Rv2780 with NAD and pyruvate==
|PDB= 2voj |SIZE=350|CAPTION= <scene name='initialview01'>2voj</scene>, resolution 2.60&Aring;
<StructureSection load='2voj' size='340' side='right'caption='[[2voj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Binding+Site+For+Residue+Nad+A+500'>AC1</scene>, <scene name='pdbsite=AC2:Binding+Site+For+Residue+2op+A+501'>AC2</scene>, <scene name='pdbsite=AC3:Binding+Site+For+Residue+Nad+C+500'>AC3</scene>, <scene name='pdbsite=AC4:Binding+Site+For+Residue+2op+C+501'>AC4</scene>, <scene name='pdbsite=AC5:Binding+Site+For+Residue+Nad+E+500'>AC5</scene> and <scene name='pdbsite=AC6:Binding+Site+For+Residue+2op+E+501'>AC6</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
<table><tr><td colspan='2'>[[2voj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOJ FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_dehydrogenase Alanine dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.1.1 1.4.1.1] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2voj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voj OCA], [https://pdbe.org/2voj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2voj RCSB], [https://www.ebi.ac.uk/pdbsum/2voj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2voj ProSAT]</span></td></tr>
|RELATEDENTRY=[[2vhv|2VHV]], [[2vhw|2VHW]], [[2vhx|2VHX]], [[2vhy|2VHY]], [[2vhz|2VHZ]], [[2voe|2VOE]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2voj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voj OCA], [http://www.ebi.ac.uk/pdbsum/2voj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2voj RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/DHA_MYCTU DHA_MYCTU] Catalyzes the reversible reductive amination of pyruvate to L-alanine. However, since the physiological environment of M.tuberculosis has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-alanine. May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.<ref>PMID:10527947</ref>
 
== Evolutionary Conservation ==
'''TERNARY COMPLEX OF M. TUBERCULOSIS RV2780 WITH NAD AND PYRUVATE'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2voj_consurf.spt"</scriptWhenChecked>
2VOJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOJ OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Alanine dehydrogenase]]
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2voj ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Single protein]]
[[Category: Ramachandran R]]
[[Category: Ramachandran, R.]]
[[Category: Tripathi SM]]
[[Category: Tripathi, S M.]]
[[Category: alanine dehydrogenase]]
[[Category: nad]]
[[Category: oxidoreductase]]
[[Category: pyruvate]]
[[Category: rv2780]]
[[Category: secreted]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:13:55 2008''

Latest revision as of 10:02, 9 May 2024

Ternary complex of M. tuberculosis Rv2780 with NAD and pyruvate

2voj, resolution 2.60Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2voj&oldid=4145242"