3dmv: Difference between revisions

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==Free of ligand binding in the hydrophobic cavity of T4 lysozyme L99A mutant==
==Free of ligand binding in the hydrophobic cavity of T4 lysozyme L99A mutant==
<StructureSection load='3dmv' size='340' side='right' caption='[[3dmv]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='3dmv' size='340' side='right'caption='[[3dmv]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3dmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DMV FirstGlance]. <br>
<table><tr><td colspan='2'>[[3dmv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DMV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[181l|181l]], [[3dke|3dke]], [[3dmx|3dmx]], [[3dmz|3dmz]], [[3dn0|3dn0]], [[3dn1|3dn1]], [[3dn2|3dn2]], [[3dn3|3dn3]], [[3dn4|3dn4]], [[3dn6|3dn6]], [[3dn8|3dn8]], [[3dna|3dna]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 BPT4])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dmv OCA], [https://pdbe.org/3dmv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dmv RCSB], [https://www.ebi.ac.uk/pdbsum/3dmv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dmv ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dmv OCA], [http://pdbe.org/3dmv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dmv RCSB], [http://www.ebi.ac.uk/pdbsum/3dmv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dmv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.  
[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bpt4]]
[[Category: Escherichia virus T4]]
[[Category: Lysozyme]]
[[Category: Large Structures]]
[[Category: Liu, L]]
[[Category: Liu L]]
[[Category: Matthews, B W]]
[[Category: Matthews BW]]
[[Category: Antimicrobial]]
[[Category: Bacteriolytic enzyme]]
[[Category: Cavity]]
[[Category: Glycosidase]]
[[Category: Halogen bond]]
[[Category: Halogenated benzene]]
[[Category: Hydrolase]]
[[Category: T4 lysozyme]]
Retrieved from "https://proteopedia.org/3dmv"