Colony-stimulating factor receptor: Difference between revisions

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<StructureSection load='4hw7' size='340' side='right' caption='Human macrophage colony stimulating factor receptor kinase domain complex with inhibitor (PDB code [[4hw7]])' scene=''>
<StructureSection load='4hw7' size='340' side='right' caption='Human macrophage colony stimulating factor receptor kinase domain complex with inhibitor (PDB code [[4hw7]])' scene='80/801744/Cv/1'>


== Function ==
== Function ==
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*'''Granulocyte-macrophage colony stimulating factor receptor''' (GM-CSFR) regulates the production and activation of of hemopoietic cells as monocytes, macrophages and granulocytesparticipates in the development, survival and activation of neutrophilic granulocytes and controls dendritic cells and T-cell function<ref>PMID:19436055</ref>.<br />
*'''Granulocyte-macrophage colony stimulating factor receptor''' (GM-CSFR) regulates the production and activation of of hemopoietic cells as monocytes, macrophages and granulocytesparticipates in the development, survival and activation of neutrophilic granulocytes and controls dendritic cells and T-cell function<ref>PMID:19436055</ref>.<br />
*'''Granulocyte colony stimulating factor receptor''' (G-CSFR) participates in the development, survival and activation of neutrophilic granulocytes and in the development of other myeloid lineages<ref>PMID:19699815</ref>.
*'''Granulocyte colony stimulating factor receptor''' (G-CSFR) participates in the development, survival and activation of neutrophilic granulocytes and in the development of other myeloid lineages<ref>PMID:19699815</ref>.
See also
*[[Immune receptors]]
*[[Cytokine receptors]]
*[[Immune receptors]]


== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==


 
The <scene name='80/801744/Cv/4'>kinase domain of M-CSFR interacts with a drug-designed inhibitor</scene> via the conserved kinase DFG motif (colored in salmon) and its gatekeeper threonine residue (colored in magenta)<ref>PMID:23493555</ref>.
</StructureSection>


==3D structures of colony-stimulating factor receptor==
==3D structures of colony-stimulating factor receptor==
[[Colony-stimulating factor receptor 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Macrophage colony stimulating factor 1 receptor or C-FMS; Domains: kinase 543-918; 2nd Igg-like 129-229; D1-D3 20-299; ectodomain 2-512
 
**[[2ogv]] - hM-CSFR kinase domain - human<br />
**[[5lxf]] – hM-CSFR residues 33-190 (mutant) <br />
 
*M-CSFR complex
 
**[[2i0v]], [[2i0y]], [[2i1m]], [[3lco]] - hM-CSFR kinase domain + inhibitor<br />
**[[3dpk]], [[3bea]], [[4hw7]], [[4r7h]], [[3krj]], [[3krl]], [[3lcd]] - hM-CSFR kinase domain (mutant) + inhibitor<br />
**[[1flt]], [[1qty]] – hM-CSFR 2nd Igg-like domain + VEGF<br />
**[[4wrm]], [[4wrl]] - hM-CSFR + M-CSF<br />
**[[3ejj]] – mM-CSFR D1-D3 + M-CSF<br />
**[[4exp]] – mM-CSFR D1-D3 + mInterleukin 34<br />
**[[4dkd]] – hM-CSFR D1-D3 + hInterleukin 34<br />
**[[4r7i]] – hM-CSFR kinase domain (mutant) + cancer drug<br />
**[[4liq]] – hM-CSFR ectodomain + antibody<br />
 
 
*Granulocyte-macrophage colony stimulating factor receptor
 
**[[4rs1]] - hGM-CSFR subunit a (mutant) + GM-CSF<br />
**[[4nkq]] - hGM-CSF CSFR subunit a (mutant) + GMCSF + cytokine receptor<br />
 
*Granulocyte colony stimulating factor receptor or colony stimulating factor 3 receptor
 
**[[1gcf]], [[1cto]] - mG-CSFR C-terminal (mutant) - NMR<br />
**[[2d9q]] - hG-CSFR Ig-CRH domain (mutant) + hG-CSF<br />
**[[1pgr]], [[1cd9]] - mG-CSFR CRH domain + hG-CSF<br />


}}
== References ==
== References ==
<references/>
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]
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