6i5z: Difference between revisions
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New page: '''Unreleased structure''' The entry 6i5z is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Papaver somniferum O-methyltransferase== | |||
<StructureSection load='6i5z' size='340' side='right'caption='[[6i5z]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6i5z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Papaver_somniferum Papaver somniferum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I5Z FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i5z OCA], [https://pdbe.org/6i5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i5z RCSB], [https://www.ebi.ac.uk/pdbsum/6i5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i5z ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SOMT1_PAPSO SOMT1_PAPSO] Methyltransferase involved in the biosynthesis of the benzylisoquinoline alkaloid noscapine (PubMed:22535422, PubMed:22653730, PubMed:29610307). Catalyzes the conversion of (S)-scoulerine to (S)-tetrahydrocolumbamine (PubMed:22535422, PubMed:22653730). Can convert (S)-tetrahydrocolumbamine to tetrahydropalmatine (PubMed:22535422). Can convert (S)-norreticuline to (S)-norcodamine (PubMed:22535422). Can convert (S)-reticuline to (S)-codamine (PubMed:22535422). Substrate preference is (S)-scoulerine > (S)-tetrahydrocolumbamine > (S)-norreticuline > (S)-reticuline (PubMed:22535422).<ref>PMID:22535422</ref> <ref>PMID:22653730</ref> <ref>PMID:29610307</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Papaver somniferum]] | |||
[[Category: Cabry MP]] | |||
[[Category: Davies GJ]] | |||
[[Category: Offen WA]] | |||
Latest revision as of 11:47, 24 January 2024
Papaver somniferum O-methyltransferase
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