6i7q: Difference between revisions
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New page: '''Unreleased structure''' The entry 6i7q is ON HOLD Authors: Chowdhury, R., Aguilera, L.S., Schofield, C.J. Description: Structure of pVHL-elongin B-elongin C (VCB) in complex with hy... |
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==Structure of pVHL-elongin B-elongin C (VCB) in complex with hydroxylated-HIF-2alpha (523-542) in the C2221 form== | |||
<StructureSection load='6i7q' size='340' side='right'caption='[[6i7q]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6i7q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I7Q FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.798Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i7q OCA], [https://pdbe.org/6i7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i7q RCSB], [https://www.ebi.ac.uk/pdbsum/6i7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i7q ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ELOB_HUMAN ELOB_HUMAN] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:7638163</ref> <ref>PMID:15590694</ref> The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:7638163</ref> <ref>PMID:15590694</ref> | |||
==See Also== | |||
*[[Elongation factor 3D structures|Elongation factor 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Aguilera | __TOC__ | ||
[[Category: Chowdhury | </StructureSection> | ||
[[Category: Schofield | [[Category: Bos taurus]] | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Aguilera LS]] | |||
[[Category: Chowdhury R]] | |||
[[Category: Schofield CJ]] | |||
Latest revision as of 11:48, 24 January 2024
Structure of pVHL-elongin B-elongin C (VCB) in complex with hydroxylated-HIF-2alpha (523-542) in the C2221 form
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