6i7x: Difference between revisions

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'''Unreleased structure'''


The entry 6i7x is ON HOLD
==Crystal Structure of the first bromodomain of BRD4 in complex with RT53==
<StructureSection load='6i7x' size='340' side='right'caption='[[6i7x]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6i7x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I7X FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H7B:2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-1-[4-(dimethylamino)piperidin-1-yl]ethanone'>H7B</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i7x OCA], [https://pdbe.org/6i7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i7x RCSB], [https://www.ebi.ac.uk/pdbsum/6i7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i7x ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).


Authors: Picaud, S., Traquete, R., Bernardes, G.J.L., Newman, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Filippakopoulos, P., Structural Genomics Consortium (SGC)
==See Also==
 
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
Description: Crystal Structure of the first bromodomain of BRD4 in complex with RT53
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Arrowsmith, C.H]]
__TOC__
[[Category: Bernardes, G.J.L]]
</StructureSection>
[[Category: Traquete, R]]
[[Category: Homo sapiens]]
[[Category: Picaud, S]]
[[Category: Large Structures]]
[[Category: Filippakopoulos, P]]
[[Category: Arrowsmith CH]]
[[Category: Newman, J]]
[[Category: Bernardes GJL]]
[[Category: Edwards, A.M]]
[[Category: Bountra C]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Edwards AM]]
[[Category: Bountra, C]]
[[Category: Filippakopoulos P]]
[[Category: Newman J]]
[[Category: Picaud S]]
[[Category: Traquete R]]
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