6i7y: Difference between revisions
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==Crystal Structure of the first bromodomain of BRD4 in complex with RT56== | |||
<StructureSection load='6i7y' size='340' side='right'caption='[[6i7y]], [[Resolution|resolution]] 1.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6i7y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I7Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H7E:[1-[4-[2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]ethanoylamino]phenyl]piperidin-4-yl]-trimethyl-azanium'>H7E</scene></td></tr> | ||
[[Category: Arrowsmith | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i7y OCA], [https://pdbe.org/6i7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i7y RCSB], [https://www.ebi.ac.uk/pdbsum/6i7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i7y ProSAT]</span></td></tr> | ||
[[Category: Bernardes | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
[[Category: Filippakopoulos | == Function == | ||
[[Category: Newman | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bernardes GJL]] | |||
[[Category: Bountra C]] | |||
[[Category: Edwards AM]] | |||
[[Category: Filippakopoulos P]] | |||
[[Category: Newman J]] | |||
[[Category: Picaud S]] | |||
[[Category: Traquete R]] | |||
Latest revision as of 11:48, 24 January 2024
Crystal Structure of the first bromodomain of BRD4 in complex with RT56
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