2c0z: Difference between revisions

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[[Image:2c0z.gif|left|200px]]<br />
<applet load="2c0z" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2c0z, resolution 1.60&Aring;" />
'''THE 1.6 A RESOLUTION CRYSTAL STRUCTURE OF NOVW: A 4-KETO-6-DEOXY SUGAR EPIMERASE FROM THE NOVOBIOCIN BIOSYNTHETIC GENE CLUSTER OF STREPTOMYCES SPHEROIDES'''<br />


==About this Structure==
==The 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides==
2C0Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_caeruleus Streptomyces caeruleus] with SO4 and EDO as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C0Z OCA].  
<StructureSection load='2c0z' size='340' side='right'caption='[[2c0z]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
[[Category: Single protein]]
== Structural highlights ==
[[Category: Streptomyces caeruleus]]
<table><tr><td colspan='2'>[[2c0z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_niveus_NCIMB_11891 Streptomyces niveus NCIMB 11891]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0Z FirstGlance]. <br>
[[Category: Buttner, M.J.]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
[[Category: Field, R.A.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Freel-Meyers, C.L.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0z OCA], [https://pdbe.org/2c0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0z RCSB], [https://www.ebi.ac.uk/pdbsum/2c0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0z ProSAT]</span></td></tr>
[[Category: Jakimowicz, P.]]
</table>
[[Category: Lawson, D.M.]]
== Function ==
[[Category: Tello, M.]]
[https://www.uniprot.org/uniprot/NOVW_STRNV NOVW_STRNV] dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase that acts together with NovU to catalyze the formation of dTDP-4-keto-6-deoxy-5-C-methyl-L-lyxo-hexose from dTDP-4-keto-6-deoxy-D-glucose in the novobiocin biosynthesis pathway, an aminocoumarin family antibiotic that targets bacterial DNA gyrases.<ref>PMID:15752721</ref> <ref>PMID:16514445</ref>
[[Category: Walsh, C.T.]]
== Evolutionary Conservation ==
[[Category: EDO]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: SO4]]
Check<jmol>
[[Category: antibiotic biosynthesis]]
  <jmolCheckbox>
[[Category: epimerase]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0z_consurf.spt"</scriptWhenChecked>
[[Category: isomerase]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: rmlc-like cupin]]
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov  5 17:55:02 2007''
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c0z ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces niveus NCIMB 11891]]
[[Category: Buttner MJ]]
[[Category: Field RA]]
[[Category: Freel-Meyers CL]]
[[Category: Jakimowicz P]]
[[Category: Lawson DM]]
[[Category: Tello M]]
[[Category: Walsh CT]]
Retrieved from "https://proteopedia.org/2c0z"