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[[Image:2yxd.gif|left|200px]]


{{Structure
==Crystal Structure of Cobalamin biosynthesis precorrin 8W decarboxylase (cbiT)==
|PDB= 2yxd |SIZE=350|CAPTION= <scene name='initialview01'>2yxd</scene>, resolution 2.30&Aring;
<StructureSection load='2yxd' size='340' side='right'caption='[[2yxd]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
<table><tr><td colspan='2'>[[2yxd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YXD FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
|GENE= cbiT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxd OCA], [https://pdbe.org/2yxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yxd RCSB], [https://www.ebi.ac.uk/pdbsum/2yxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yxd ProSAT], [https://www.topsan.org/Proteins/RSGI/2yxd TOPSAN]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxd OCA], [http://www.ebi.ac.uk/pdbsum/2yxd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2yxd RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/CBIT_METJA CBIT_METJA] Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7 (By similarity).
 
== Evolutionary Conservation ==
'''Crystal Structure of Cobalamin biosynthesis precorrin 8W decarboxylase (cbiT)'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yx/2yxd_consurf.spt"</scriptWhenChecked>
2YXD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXD OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: Methanocaldococcus jannaschii]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Single protein]]
  </jmolCheckbox>
[[Category: Bessho, Y.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yxd ConSurf].
[[Category: Padmanabhan, B.]]
<div style="clear:both"></div>
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
__TOC__
[[Category: Yokoyama, S.]]
</StructureSection>
[[Category: alpha and beta protein (a/b) class]]
[[Category: Large Structures]]
[[Category: methyltransferase superfamily]]
[[Category: Methanocaldococcus jannaschii DSM 2661]]
[[Category: national project on protein structural and functional analyse]]
[[Category: Bessho Y]]
[[Category: nppsfa]]
[[Category: Padmanabhan B]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: Yokoyama S]]
[[Category: rsgi]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:16:24 2008''
Retrieved from "https://proteopedia.org/2yxd"