6n2u: Difference between revisions
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New page: '''Unreleased structure''' The entry 6n2u is ON HOLD Authors: Park, H., Jung, J.H., Luo, J.L. Description: IL-8 Structure from Bacterial Expression Source [[Category: Unreleased Struct... |
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==IL-8 Structure from Bacterial Expression Source== | |||
<StructureSection load='6n2u' size='340' side='right'caption='[[6n2u]], [[Resolution|resolution]] 1.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6n2u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N2U FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.254Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n2u OCA], [https://pdbe.org/6n2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n2u RCSB], [https://www.ebi.ac.uk/pdbsum/6n2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n2u ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IL8_HUMAN IL8_HUMAN] IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.<ref>PMID:2145175</ref> <ref>PMID:2212672</ref> <ref>PMID:11978786</ref> | |||
==See Also== | |||
*[[Interleukin 3D structures|Interleukin 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Jung JH]] | |||
[[Category: Luo JL]] | |||
[[Category: Park H]] | |||
Latest revision as of 06:44, 11 October 2023
IL-8 Structure from Bacterial Expression Source
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