6n5y: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "6n5y" [edit=sysop:move=sysop] |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of the SNX5 PX domain in complex with the CI-MPR (space group P212121 - Form 1)== | |||
<StructureSection load='6n5y' size='340' side='right'caption='[[6n5y]], [[Resolution|resolution]] 2.26Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6n5y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N5Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n5y OCA], [https://pdbe.org/6n5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n5y RCSB], [https://www.ebi.ac.uk/pdbsum/6n5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n5y ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SNX5_HUMAN SNX5_HUMAN] May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation.<ref>PMID:18854019</ref> <ref>PMID:21048941</ref> [https://www.uniprot.org/uniprot/MPRI_HUMAN MPRI_HUMAN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.<ref>PMID:10900005</ref> | |||
==See Also== | |||
*[[Sorting nexin 3D structures|Sorting nexin 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Collins | __TOC__ | ||
[[Category: Paul | </StructureSection> | ||
[[Category: Weeratunga | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Collins B]] | |||
[[Category: Paul B]] | |||
[[Category: Weeratunga S]] | |||
Latest revision as of 14:46, 13 March 2024
Crystal structure of the SNX5 PX domain in complex with the CI-MPR (space group P212121 - Form 1)
| ||||||||||||
