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==Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with NMS==
==Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with NMS==
<StructureSection load='5zkc' size='340' side='right' caption='[[5zkc]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5zkc' size='340' side='right'caption='[[5zkc]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5zkc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZKC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZKC FirstGlance]. <br>
<table><tr><td colspan='2'>[[5zkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZKC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3C0:N-METHYL+SCOPOLAMINE'>3C0</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5zk8|5zk8]], [[5zkb|5zkb]], [[5zk3|5zk3]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3C0:N-METHYL+SCOPOLAMINE'>3C0</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHRM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zkc OCA], [https://pdbe.org/5zkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zkc RCSB], [https://www.ebi.ac.uk/pdbsum/5zkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zkc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zkc OCA], [http://pdbe.org/5zkc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zkc RCSB], [http://www.ebi.ac.uk/pdbsum/5zkc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zkc ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.  
[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5zkc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5zkc" style="background-color:#fffaf0;"></div>
==See Also==
*[[Muscarinic acetylcholine receptor|Muscarinic acetylcholine receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Hirata, K]]
[[Category: Large Structures]]
[[Category: Horita, S]]
[[Category: Hirata K]]
[[Category: Iwata, S]]
[[Category: Horita S]]
[[Category: Kinoshita, M]]
[[Category: Iwata S]]
[[Category: Kobayashi, T]]
[[Category: Kinoshita M]]
[[Category: Kobilka, B K]]
[[Category: Kobayashi T]]
[[Category: Maeda, S]]
[[Category: Kobilka BK]]
[[Category: Murata, T]]
[[Category: Maeda S]]
[[Category: Suno, R]]
[[Category: Murata T]]
[[Category: Tawaramoto, M S]]
[[Category: Suno R]]
[[Category: Tsujimoto, H]]
[[Category: Tawaramoto MS]]
[[Category: Yamamoto, M]]
[[Category: Tsujimoto H]]
[[Category: Yamashita, K]]
[[Category: Yamamoto M]]
[[Category: Yasuda, S]]
[[Category: Yamashita K]]
[[Category: Gpcr crystallography]]
[[Category: Yasuda S]]
[[Category: Membrane protein-inhibitor complex]]
[[Category: Rationally thermostabilized mutant]]
Retrieved from "https://proteopedia.org/5zkc"