3ewe: Difference between revisions

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==Crystal Structure of the Nup85/Seh1 Complex==
==Crystal Structure of the Nup85/Seh1 Complex==
<StructureSection load='3ewe' size='340' side='right' caption='[[3ewe]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='3ewe' size='340' side='right'caption='[[3ewe]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ewe]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EWE FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ewe]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EWE FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SEH1, YGL100W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), J1624, NUP85, RAT9, YJR042W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ewe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ewe OCA], [http://pdbe.org/3ewe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ewe RCSB], [http://www.ebi.ac.uk/pdbsum/3ewe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ewe ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ewe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ewe OCA], [https://pdbe.org/3ewe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ewe RCSB], [https://www.ebi.ac.uk/pdbsum/3ewe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ewe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SEH1_YEAST SEH1_YEAST]] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Involved in nuclear poly(A)+ RNA export and NPC biogenesis. It is also required for normal nuclear morphology. Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis.<ref>PMID:8565072</ref> <ref>PMID:11823431</ref> <ref>PMID:12206772</ref> <ref>PMID:21454883</ref>  [[http://www.uniprot.org/uniprot/NUP85_YEAST NUP85_YEAST]] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP85 is involved in nuclear poly(A)+ RNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.<ref>PMID:8816998</ref> <ref>PMID:9774696</ref> <ref>PMID:11071906</ref> <ref>PMID:12543930</ref> <ref>PMID:11823431</ref> <ref>PMID:12730220</ref>
[https://www.uniprot.org/uniprot/NUP85_YEAST NUP85_YEAST] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP85 is involved in nuclear poly(A)+ RNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.<ref>PMID:8816998</ref> <ref>PMID:9774696</ref> <ref>PMID:11071906</ref> <ref>PMID:12543930</ref> <ref>PMID:11823431</ref> <ref>PMID:12730220</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/3ewe_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/3ewe_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[Nucleoporin|Nucleoporin]]
*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Large Structures]]
[[Category: Brohawn, S G]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Leksa, N C]]
[[Category: Brohawn SG]]
[[Category: Rajashankar, K R]]
[[Category: Leksa NC]]
[[Category: Schwartz, T U]]
[[Category: Rajashankar KR]]
[[Category: Cell membrane]]
[[Category: Schwartz TU]]
[[Category: Membrane]]
[[Category: Membrane protein]]
[[Category: Mrna transport]]
[[Category: Nuclear pore complex]]
[[Category: Nucleoporin]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Protein transport]]
[[Category: Structural protein]]
[[Category: Translocation]]
[[Category: Transport]]
[[Category: Wd repeat]]
Retrieved from "https://proteopedia.org/3ewe"