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| [[Image:333d.gif|left|200px]]
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| {{Structure
| | ==THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES== |
| |PDB= 333d |SIZE=350|CAPTION= <scene name='initialview01'>333d</scene>, resolution 2.520Å
| | <StructureSection load='333d' size='340' side='right'caption='[[333d]], [[Resolution|resolution]] 2.52Å' scene=''> |
| |SITE=
| | == Structural highlights == |
| |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=I:INOSINIC+ACID'>I</scene>
| | <table><tr><td colspan='2'>[[333d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=333D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=333D FirstGlance]. <br> |
| |ACTIVITY=
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.52Å</td></tr> |
| |GENE=
| | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| |DOMAIN=
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=333d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=333d OCA], [https://pdbe.org/333d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=333d RCSB], [https://www.ebi.ac.uk/pdbsum/333d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=333d ProSAT]</span></td></tr> |
| |RELATEDENTRY=
| | </table> |
| |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=333d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=333d OCA], [http://www.ebi.ac.uk/pdbsum/333d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=333d RCSB]</span>
| | __TOC__ |
| }}
| | </StructureSection> |
| | | [[Category: Large Structures]] |
| '''THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES'''
| | [[Category: Baeyens KJ]] |
| | | [[Category: Carter RJ]] |
| | | [[Category: Holbrook SR]] |
| ==Overview==
| | [[Category: SantaLucia Jr J]] |
| The X-ray crystallographic structure of the RNA duplex [r(CGCAIGCG)]2 has been refined to 2.5 A. It shows a symmetric internal loop of two non-Watson-Crick base pairs which form in the middle of the duplex. The tandem A-I/I-A pairs are related by a crystallographic two-fold axis. Both A(anti)-I(anti) mismatches are in a head-to-head conformation forming hydrogen bonds using the Watson-Crick positions. The octamer duplexes stack above one another in the cell forming a pseudo-infinite helix throughout the crystal. A hydrated calcium ion bridges between the 3'-terminal of one molecule and the backbone of another. The tandem A-I mismatches are incorporated with only minor distortion to the backbone. This is in contrast to the large helical perturbations often produced by sheared G-A pairs in RNA oligonucleotides.
| | [[Category: Turner DH]] |
| | |
| ==About this Structure==
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| 333D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=333D OCA].
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| ==Reference==
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| The crystal structure of an RNA oligomer incorporating tandem adenosine-inosine mismatches., Carter RJ, Baeyens KJ, SantaLucia J, Turner DH, Holbrook SR, Nucleic Acids Res. 1997 Oct 15;25(20):4117-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9321667 9321667]
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| [[Category: Protein complex]] | |
| [[Category: Baeyens, K J.]] | |
| [[Category: Carter, R J.]] | |
| [[Category: Holbrook, S R.]] | |
| [[Category: Jr., J SantaLucia.]] | |
| [[Category: Turner, D H.]] | |
| [[Category: a-rna]]
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| [[Category: double helix]]
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| [[Category: internal loop]]
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| [[Category: mismatched]]
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:21:28 2008''
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