3g73: Difference between revisions

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==Structure of the FOXM1 DNA binding==
==Structure of the FOXM1 DNA binding==
<StructureSection load='3g73' size='340' side='right' caption='[[3g73]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
<StructureSection load='3g73' size='340' side='right'caption='[[3g73]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3g73]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G73 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3g73]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G73 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FKHL16, FOXM1, HFH11, MPP2, WIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g73 OCA], [http://pdbe.org/3g73 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g73 RCSB], [http://www.ebi.ac.uk/pdbsum/3g73 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g73 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g73 OCA], [https://pdbe.org/3g73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g73 RCSB], [https://www.ebi.ac.uk/pdbsum/3g73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g73 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FOXM1_HUMAN FOXM1_HUMAN]] Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.<ref>PMID:17101782</ref> <ref>PMID:19160488</ref> <ref>PMID:20360045</ref>
[https://www.uniprot.org/uniprot/FOXM1_HUMAN FOXM1_HUMAN] Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.<ref>PMID:17101782</ref> <ref>PMID:19160488</ref> <ref>PMID:20360045</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Forkhead box protein|Forkhead box protein]]
*[[FOX 3D structures|FOX 3D structures]]
*[[Forkhead box protein M1|Forkhead box protein M1]]
*[[Forkhead box protein M1|Forkhead box protein M1]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Hibbert, R G]]
[[Category: Large Structures]]
[[Category: Littler, D R]]
[[Category: Hibbert RG]]
[[Category: Medema, R H]]
[[Category: Littler DR]]
[[Category: Perrakis, A]]
[[Category: Medema RH]]
[[Category: Activator]]
[[Category: Perrakis A]]
[[Category: Dna-binding]]
[[Category: Dna-binding domain]]
[[Category: Forkhead]]
[[Category: Forkhead transcription factor]]
[[Category: Foxm1]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription-dna complex]]
[[Category: Winged helix]]
Retrieved from "https://proteopedia.org/3g73"