Exophilin: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (10 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load=' | <StructureSection load='4np9' size='400' side='right' caption='Rat rabphilin-3A C2A domain complex with inositol triphosphate and sulfate (PDB code [[4np9]])' scene='80/802738/Cv/1'> | ||
== Function == | == Function == | ||
'''Exophilin''' (EXP) are [[Synaptotagmin]]-like membrane proteins which bind Ca+2 and phospholipids are involved in synaptic vesicle docking. | '''Exophilin''' (EXP) are [[Synaptotagmin]]-like membrane proteins which bind Ca+2 ions and phospholipids are involved in synaptic vesicle docking. | ||
* EXP-1 or '''rabphilin-3A''' is a Rab3 effector at the synapse. Rab3A is a GTP-binding protein of synaptic vesicle that regulates vesicle exocytosis<ref>PMID:10407024</ref>. EXP-1 regulates synaptic vesicle traffic and does so at distinct stages of both the exocytotic and endocytotic pathways<ref>PMID:9450942</ref>.<br /> | * '''EXP-1''' or '''rabphilin-3A''' is a Rab3 effector at the synapse. Rab3A is a GTP-binding protein of synaptic vesicle that regulates vesicle exocytosis<ref>PMID:10407024</ref>. EXP-1 regulates synaptic vesicle traffic and does so at distinct stages of both the exocytotic and endocytotic pathways<ref>PMID:9450942</ref>.<br /> | ||
* EXP-2 or '''granuphilin''' is a Rab27a effector. It is involved in tethering insulin granules to the plasma membrane in regulated exocytosis<ref>PMID:16216924</ref> by interacting with Rab27a and [[Syntaxin]]-1a<ref>PMID:15028737</ref>.<br />. | * '''EXP-2''' or '''granuphilin''' is a Rab27a effector. It is involved in tethering insulin granules to the plasma membrane in regulated exocytosis<ref>PMID:16216924</ref> by interacting with Rab27a and [[Syntaxin]]-1a<ref>PMID:15028737</ref>.<br /> | ||
* '''EXP-3''' or '''melanophilin''' links [[Myosin]] Va and the cargo vesicles in the cells through activation of ATPase producing the motor activity<ref>PMID:15760894</ref>.<br /> | |||
== Relevance == | == Relevance == | ||
EXP-1 is a diagnostically useful autoantigen for lymphocytic infundibulo-neurohypophysitis<ref>PMID:25919460</ref>. Reduction of EXP-1 immunoreactivity was found in patients of Alzheimer disease<ref>PMID:24200817</ref>. | EXP-1 is a diagnostically useful autoantigen for lymphocytic infundibulo-neurohypophysitis<ref>PMID:25919460</ref>. Reduction of EXP-1 immunoreactivity was found in patients of Alzheimer disease<ref>PMID:24200817</ref>. EXP-4 or '''synaptotagmin-like protein 2''' is associated with the metastatic potential of ovarian carcinoma<ref>PMID:27220283</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
</ | The <scene name='80/802738/Cv/3'>C2A domain of rabphilin-3A binds the phospholipid molecule</scene> and the phosphate ions and <scene name='80/802738/Cv/6'>in a groove</scene> in the calcium-binding polybasic region of the protein<ref>PMID:24302762</ref>. The rabphilin-3A residues interactiong with inositol triphosphate are colored according to their charge ({{Template:ColorKey_Charge_Anionic}} / {{Template:ColorKey_Charge_Cationic}}). Water molecules are shown as red spheres. | ||
==3D structures of exophilin== | ==3D structures of exophilin== | ||
[[Exophilin 3D structures]] | |||
</StructureSection> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
