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[[Image:3app.gif|left|200px]]


{{Structure
==STRUCTURE AND REFINEMENT OF PENICILLOPEPSIN AT 1.8 ANGSTROMS RESOLUTION==
|PDB= 3app |SIZE=350|CAPTION= <scene name='initialview01'>3app</scene>, resolution 1.8&Aring;
<StructureSection load='3app' size='340' side='right'caption='[[3app]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[3app]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Penicillium_janthinellum Penicillium janthinellum]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2app 2app] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1app 1app]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3APP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3APP FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Penicillopepsin Penicillopepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.20 3.4.23.20] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3app FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3app OCA], [https://pdbe.org/3app PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3app RCSB], [https://www.ebi.ac.uk/pdbsum/3app PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3app ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3app FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3app OCA], [http://www.ebi.ac.uk/pdbsum/3app PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3app RCSB]</span>
[https://www.uniprot.org/uniprot/PEPA1_PENJA PEPA1_PENJA] Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but can also activate trypsinogen and hydrolyze the B chain of insulin between positions 'Gly-20' and 'Glu-21'.<ref>PMID:4946839</ref>
}}
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ap/3app_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3app ConSurf].
<div style="clear:both"></div>


'''STRUCTURE AND REFINEMENT OF PENICILLOPEPSIN AT 1.8 ANGSTROMS RESOLUTION'''
==See Also==
 
*[[Penicillopepsin|Penicillopepsin]]
 
*[[Pepsin|Pepsin]]
==About this Structure==
== References ==
3APP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Penicillium_janthinellum Penicillium janthinellum]. This structure supersedes the now removed PDB entries 2APP and 1APP. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3APP OCA].
<references/>
 
__TOC__
==Reference==
</StructureSection>
Structure and refinement of penicillopepsin at 1.8 A resolution., James MN, Sielecki AR, J Mol Biol. 1983 Jan 15;163(2):299-361. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/6341600 6341600]
[[Category: Large Structures]]
[[Category: Penicillium janthinellum]]
[[Category: Penicillium janthinellum]]
[[Category: Penicillopepsin]]
[[Category: James MNG]]
[[Category: Single protein]]
[[Category: Sielecki AR]]
[[Category: James, M N.G.]]
[[Category: Sielecki, A R.]]
[[Category: hydrolase (acid proteinase)]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:22:25 2008''
Retrieved from "https://proteopedia.org/3app"