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==Crystal structure of PSD-95 tandem PDZ domains 1 and 2==
==Crystal structure of PSD-95 tandem PDZ domains 1 and 2==
<StructureSection load='3gsl' size='340' side='right' caption='[[3gsl]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='3gsl' size='340' side='right'caption='[[3gsl]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3gsl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GSL FirstGlance]. <br>
<table><tr><td colspan='2'>[[3gsl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GSL FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2i1n|2i1n]], [[2fe5|2fe5]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dlg4, Dlgh4, PSD-95, Psd95 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gsl OCA], [https://pdbe.org/3gsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gsl RCSB], [https://www.ebi.ac.uk/pdbsum/3gsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gsl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gsl OCA], [http://pdbe.org/3gsl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gsl RCSB], [http://www.ebi.ac.uk/pdbsum/3gsl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gsl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 3gsl" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3gsl" style="background-color:#fffaf0;"></div>
==See Also==
*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Imperiali, B]]
[[Category: Rattus norvegicus]]
[[Category: Olivier, N B]]
[[Category: Imperiali B]]
[[Category: Sainlos, M]]
[[Category: Olivier NB]]
[[Category: Cell junction]]
[[Category: Sainlos M]]
[[Category: Cell membrane]]
[[Category: Dlg4]]
[[Category: Glur6]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Palmitate]]
[[Category: Pdz domain]]
[[Category: Phosphoprotein]]
[[Category: Postsynaptic cell membrane]]
[[Category: Psd-95]]
[[Category: Sap-90]]
[[Category: Sh3 domain]]
[[Category: Structural protein]]
[[Category: Synapse]]
[[Category: Tandem]]
Retrieved from "https://proteopedia.org/3gsl"