6iw7: Difference between revisions

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'''Unreleased structure'''


The entry 6iw7 is ON HOLD
==structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease==
 
<StructureSection load='6iw7' size='340' side='right'caption='[[6iw7]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
Authors: Bao, R., Luo, Y.Z., Zhu, Y.B., Yang, Y., Zhou, Y.Z.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6iw7]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_CDC1551 Mycobacterium tuberculosis CDC1551] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IW7 FirstGlance]. <br>
Description: structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.692121&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AV3:4-[(4-fluoro-2-methyl-3H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline'>AV3</scene>, <scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
[[Category: Zhou, Y.Z]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iw7 OCA], [https://pdbe.org/6iw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iw7 RCSB], [https://www.ebi.ac.uk/pdbsum/6iw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iw7 ProSAT]</span></td></tr>
[[Category: Yang, Y]]
</table>
[[Category: Zhu, Y.B]]
== Function ==
[[Category: Luo, Y.Z]]
[https://www.uniprot.org/uniprot/CLPP2_MYCTU CLPP2_MYCTU] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). Degrades anti-sigma-D factor RsdA when present in a complex with ClpP1 and ClpX. Degrades anti-sigma-E factor RseA in the presence of ClpC1. Does not seem to act on anti-sigma-L factor RslA.[HAMAP-Rule:MF_00444]<ref>PMID:20025669</ref> <ref>PMID:23314154</ref>
[[Category: Bao, R]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis CDC1551]]
[[Category: Synthetic construct]]
[[Category: Bao R]]
[[Category: Luo YF]]
[[Category: Yang Y]]
[[Category: Zhou YZ]]
[[Category: Zhu YB]]
Retrieved from "https://proteopedia.org/6iw7"