6nao: Difference between revisions

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~~'''Unreleased structure'''~~

~~The~~ entry 6nao ~~is ON HOLD~~

==Discovery of a high affinity inhibitor of cGAS==

== Structural highlights ==

<table><tr><td colspan='2'>[[6nao]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5v8n 5v8n]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NAO OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=6NAO FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.23Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KHM:(1R,2S)-2-[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic+acid'>KHM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=6nao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nao OCA], [https://pdbe.org/6nao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nao RCSB], [https://www.ebi.ac.uk/pdbsum/6nao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nao ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>

~~Authors: Hall, J., Hall, J.~~

==See Also==

*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]]

~~Description~~: ~~Discovery of a high affinity inhibitor of cGAS~~

== References ==

[[Category: ~~Unreleased~~ Structures]]

[[Category: Hall, J]]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Hall J]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6nao is ON HOLD
+==Discovery of a high affinity inhibitor of cGAS==
+<StructureSection load='6nao' size='340' side='right'caption='[[6nao]], [[Resolution|resolution]] 3.23&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6nao]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5v8n 5v8n]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NAO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.23&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KHM:(1R,2S)-2-[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic+acid'>KHM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nao OCA], [https://pdbe.org/6nao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nao RCSB], [https://www.ebi.ac.uk/pdbsum/6nao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nao ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
-Authors: Hall, J., Hall, J.
+==See Also==
+*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]]
-Description: Discovery of a high affinity inhibitor of cGAS
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Hall, J]]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Hall J]]