3bf5: Difference between revisions

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[[Image:3bf5.jpg|left|200px]]


{{Structure
==Crystal structure of putative ribokinase (10640157) from Thermoplasma acidophilum at 1.91 A resolution==
|PDB= 3bf5 |SIZE=350|CAPTION= <scene name='initialview01'>3bf5</scene>, resolution 1.910&Aring;
<StructureSection load='3bf5' size='340' side='right'caption='[[3bf5]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PGO:1,2-PROPANEDIOL'>PGO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
<table><tr><td colspan='2'>[[3bf5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum_DSM_1728 Thermoplasma acidophilum DSM 1728]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BF5 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
|GENE= 10640157, Ta0880 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273075 Thermoplasma acidophilum DSM 1728])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bf5 OCA], [https://pdbe.org/3bf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bf5 RCSB], [https://www.ebi.ac.uk/pdbsum/3bf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bf5 ProSAT], [https://www.topsan.org/Proteins/JCSG/3bf5 TOPSAN]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bf5 OCA], [http://www.ebi.ac.uk/pdbsum/3bf5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bf5 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/NK_THEAC NK_THEAC] Nucleoside kinase with broad substrate specificity. Catalyzes the phosphorylation of a variety of nucleosides to the corresponding nucleoside 5'-mono-phosphate in the presence of phosphate donors and divalent cations. Displays the most efficient activity with guanosine, followed by inosine, cytidine, and adenosine. Negligible enzymatic activity is detected with thymidine, uridine, and 2-deoxyadenosine. ATP is the most efficient phosphate donor, but can also use GTP and ITP. Shows no sugar kinase activity, since it is unable to phosphorylate ribose, fructose-1-phosphate, or fructose-6-phosphate.<ref>PMID:23161756</ref>
 
== Evolutionary Conservation ==
'''Crystal structure of putative ribokinase (10640157) from Thermoplasma acidophilum at 1.91 A resolution'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bf/3bf5_consurf.spt"</scriptWhenChecked>
3BF5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum_dsm_1728 Thermoplasma acidophilum dsm 1728]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BF5 OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: Single protein]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Thermoplasma acidophilum dsm 1728]]
  </jmolCheckbox>
[[Category: JCSG, Joint Center for Structural Genomics.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bf5 ConSurf].
[[Category: 10640157]]
<div style="clear:both"></div>
[[Category: jcsg]]
== References ==
[[Category: joint center for structural genomic]]
<references/>
[[Category: protein structure initiative]]
__TOC__
[[Category: psi-2]]
</StructureSection>
[[Category: putative ribokinase]]
[[Category: Large Structures]]
[[Category: structural genomic]]
[[Category: Thermoplasma acidophilum DSM 1728]]
[[Category: transferase]]
 
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Retrieved from "https://proteopedia.org/3bf5"