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==Crystal structure of Schistosome eIF4E complexed with m7GpppG and 4E-BP==
==Crystal structure of Schistosome eIF4E complexed with m7GpppG and 4E-BP==
<StructureSection load='3hxi' size='340' side='right' caption='[[3hxi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3hxi' size='340' side='right'caption='[[3hxi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3hxi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HXI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HXI FirstGlance]. <br>
<table><tr><td colspan='2'>[[3hxi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HXI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTG:7-METHYL-GUANOSINE-5-TRIPHOSPHATE-5-GUANOSINE'>GTG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hxg|3hxg]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTG:7-METHYL-GUANOSINE-5-TRIPHOSPHATE-5-GUANOSINE'>GTG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">eif4e ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6183 Blood fluke])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hxi OCA], [https://pdbe.org/3hxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hxi RCSB], [https://www.ebi.ac.uk/pdbsum/3hxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hxi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hxi OCA], [http://pdbe.org/3hxi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hxi RCSB], [http://www.ebi.ac.uk/pdbsum/3hxi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hxi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/4EBP1_HUMAN 4EBP1_HUMAN]] Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.<ref>PMID:7935836</ref>
[https://www.uniprot.org/uniprot/4EBP1_HUMAN 4EBP1_HUMAN] Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.<ref>PMID:7935836</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Eukaryotic initiation factor|Eukaryotic initiation factor]]
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Blood fluke]]
[[Category: Homo sapiens]]
[[Category: Davis, R E]]
[[Category: Large Structures]]
[[Category: Jones, D N.M]]
[[Category: Schistosoma mansoni]]
[[Category: Liu, W]]
[[Category: Davis RE]]
[[Category: Zhao, R]]
[[Category: Jones DNM]]
[[Category: Acetylation]]
[[Category: Liu W]]
[[Category: Phosphoprotein]]
[[Category: Zhao R]]
[[Category: Protein synthesis inhibitor]]
[[Category: Protein-mrna cap complex]]
[[Category: Translation]]
[[Category: Translation regulation]]
Retrieved from "https://proteopedia.org/3hxi"