3hij: Difference between revisions

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==Crystal structure of dihydrodipicolinate synthase from Bacillus anthracis in complex with its substrate, pyruvate==
==Crystal structure of dihydrodipicolinate synthase from Bacillus anthracis in complex with its substrate, pyruvate==
<StructureSection load='3hij' size='340' side='right' caption='[[3hij]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='3hij' size='340' side='right'caption='[[3hij]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3hij]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HIJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[3hij]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HIJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xl9|1xl9]], [[1xky|1xky]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hij OCA], [https://pdbe.org/3hij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hij RCSB], [https://www.ebi.ac.uk/pdbsum/3hij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hij ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dapA-2, dapA2, BAS3650, BA_3935, GBAA3935, GBAA_3935 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hij OCA], [http://pdbe.org/3hij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hij RCSB], [http://www.ebi.ac.uk/pdbsum/3hij PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hij ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q81WN7_BACAN Q81WN7_BACAN]] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA) (By similarity).[SAAS:SAAS020625_004_011311][HAMAP-Rule:MF_00418]  
[https://www.uniprot.org/uniprot/A0A6L7H340_BACAN A0A6L7H340_BACAN] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).[ARBA:ARBA00003294][HAMAP-Rule:MF_00418]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/3hij_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/3hij_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dobson, R C.J]]
[[Category: Bacillus anthracis]]
[[Category: Perugini, M A]]
[[Category: Large Structures]]
[[Category: Scally, S W]]
[[Category: Dobson RCJ]]
[[Category: Voss, J E]]
[[Category: Perugini MA]]
[[Category: Amino-acid biosynthesis]]
[[Category: Scally SW]]
[[Category: Diaminopimelate biosynthesis]]
[[Category: Voss JE]]
[[Category: Lyase]]
[[Category: Lysine biosynthesis]]
[[Category: Pyruvate]]
[[Category: Schiff base]]
[[Category: Tetramer]]
[[Category: Tim barrel]]
Retrieved from "https://proteopedia.org/3hij"