3c5h: Difference between revisions

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[[Image:3c5h.jpg|left|200px]]


{{Structure
==Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP)==
|PDB= 3c5h |SIZE=350|CAPTION= <scene name='initialview01'>3c5h</scene>, resolution 1.800&Aring;
<StructureSection load='3c5h' size='340' side='right'caption='[[3c5h]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+302'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Residue+A+303'>AC2</scene>, <scene name='pdbsite=AC3:Gnp+Binding+Site+For+Residue+A+301'>AC3</scene>, <scene name='pdbsite=AC4:Unx+Binding+Site+For+Residue+A+304'>AC4</scene>, <scene name='pdbsite=AC5:Unx+Binding+Site+For+Residue+A+305'>AC5</scene>, <scene name='pdbsite=AC6:Unx+Binding+Site+For+Residue+A+307'>AC6</scene> and <scene name='pdbsite=AC7:Unx+Binding+Site+For+Residue+A+308'>AC7</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>
<table><tr><td colspan='2'>[[3c5h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C5H FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
|GENE= GRLF1, GRF1, KIAA1722 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5h OCA], [https://pdbe.org/3c5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c5h RCSB], [https://www.ebi.ac.uk/pdbsum/3c5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5h ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5h OCA], [http://www.ebi.ac.uk/pdbsum/3c5h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3c5h RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/RHG35_HUMAN RHG35_HUMAN] Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.<ref>PMID:1894621</ref>
 
== Evolutionary Conservation ==
'''Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP)'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/3c5h_consurf.spt"</scriptWhenChecked>
3C5H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5H OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c5h ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev A]]
[[Category: Bountra, C.]]
[[Category: Bountra C]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: MacKenzie, F.]]
[[Category: MacKenzie F]]
[[Category: Park, H.]]
[[Category: Park H]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Shen L]]
[[Category: Shen, L.]]
[[Category: Tempel W]]
[[Category: Tempel, W.]]
[[Category: Tong Y]]
[[Category: Tong, Y.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: alternative splicing]]
[[Category: anti-oncogene]]
[[Category: cell cycle]]
[[Category: cytoplasm]]
[[Category: dna-binding]]
[[Category: glucorticoid receptor]]
[[Category: gtpase]]
[[Category: gtpase activation]]
[[Category: nucleus]]
[[Category: phosphoprotein]]
[[Category: ra]]
[[Category: repressor]]
[[Category: sgc]]
[[Category: signaling protein]]
[[Category: structural genomics consortium]]
[[Category: transcription]]
[[Category: transcription regulation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:30:47 2008''
Retrieved from "https://proteopedia.org/3c5h"